Fetal and Neonatal Physiology-4판-2 Vol Set

Fetal and Neonatal Physiology, 4th Edition Expert Consult - Online and Print, 2-Volume Set
Expected Release Date: 09.16.2011

Fetal and Neonatal Physiology, edited by Drs. Polin, Fox, and Abman, focuses on physiologic developments of the fetus
and newborn and their impact on the clinical practice of neonatology. A must for practice, this 4th edition brings you
the latest information on genetic therapy, intrauterine infections, brain protection and neuroimaging, and much more.
You'll also have easy access to the complete contents and illustrations online at expertconsult.com.

Fetal and Neonatal Physiology, Expert Consult - Online and Print, 2-Volume Set, 4th Edition
By Richard A. Polin, MD, William W. Fox, MD and Steven H. Abman, MD

I. Genetics: Genetics

II. Embryology: Embryology . Regulation of Embryogenesis . Pathophysiology of Congenital Malformations

III. The Placenta: Placental Development . Regulation of the Placental Circulation . Mechanisms of Transfer Across the
Human Placenta . Endocrine and Paracrine Function of the Human Placenta . Placental Proteins . Placental Separation at
Birth . Multiple Pregnancy

IV. Developmental Pharmacology and Pharmacokinetics: Basic Pharmacologic Principles . Basic Pharmacokinetic
Principles . Physiochemical and Structural Properties Regulating Placental Drug Transfer . Genetic Regulation of Drug
Metabolism . Drug Distribution During Fetal Life . Drug Protein Binding During Development . Development of Renal
Excretion of Drugs During Ontogeny . Pharmacodynamics and Receptor Sensitivity During Development . Drug Abuse During
Fetal and Neonatal Life . Sympathoadrenal Mechanisms During Development . Developmental Neuropharmacology . Physiologic
Differences of Clinical Significance . Therapeutic Drug Monitoring in the Newborn . Drug Excretion during Lactation

V.Intrauterine Growth: Intrauterine Growth and Nutrition

VI. Postnatal Growth and Nutrition: Infant Growth in the First Year of Life . Endocrine and Other Factors Affecting
Growth . Water Requirements . Energy Requirements . Protein Requirements . Carbohydrate Requirements . Fat Metabolism
and Requirements . Mineral and Trace Element Requirements . Vitamin Requirements . Human Milk Composition and Function
in the Infant . Types and Methods of Feeding for Infants . Nutritional Assessment . Growth Outcome of Critically Ill
Neonates

VII. Perinatal Iron, Trace Minerals, and Vitamin Metabolism: Iron Metabolism during Fetal and Neonatal Life . Trace
Element Metabolism in the Fetus and Neonate . Metabolism of Vitamin A and Water Soluble Vitamins During Fetal and
Neonatal Life . Vitamin E Metabolism in the Fetus and Neonate . Vitamin K Metabolism during the Fetal and Neonatal
Periods

VIII. Lipid Metabolism in the Fetus and Newborn: Placental Transport of Free Fatty Acids, Glycerol, and Ketone Bodies .
Lipid Accretion in the Fetus and Newborn . Brown Adipose Tissue: Development and Function . Lipids and an Energy Source
for the Premature and Full-Term Neonate . Ketone Body Production and Metabolism in the Fetus and Newborn . Very Long
Chain Fatty Acids in the Developing Retina and Brain . Physiological Effects of Lipid Infusions . Developmental
Physiology of Lipoproteins and Cholesterol . Lipoprotein Lipase

IX. Carbohydrate Metabolism: Metabolism of Glucose and Methods of Investigation in the Fetus and Newborn . Maternal
Metabolism During Pregnancy . Carbohydrate Metabolism in the Fetus . Role of Glucoregulatory Hormones on Hepatic
Glucose Metabolism During the Perinatal Period . Cell Glucose Transport and Glucose Handling During Fetal and Neonatal
Development . Glucose Metabolism During the Transition to Postnatal Life . Hypoglycemia and Hyperglycemia in the Newborn

X. Protein Metabolism: General Concepts of Protein Metabolism . Fetal Requirements and Placental Transfer of
Nitrogenous Compounds . Nitrogen Sources for the Newborn . Protein Metabolism in the Newborn . Protein and Amino Acid
Requirements . Modification of Protein Metabolism Because of Disease

XI. Thermoregulation: Perinatal Thermal Physiology . Neonatal Thermal Physiology . Physics and Physiology of Human
Incubation . Temperature Measurement in the Preterm Newborn . Incubator Management

XII. Skin: Structural and Biochemical Organogenesis of Skin and Cutaneous Appendages in the Fetus and Newborn .
Development of the Cutaneous Circulation . Composition of Skin Lipids . Sweating in the Neonate . pH Patterns in
Newborn Skin . Skin Barrier Function . Bacterial Colonization of the Skin of the Newborn

XIII. Fetal and Neonatal Cardiovascular Physiology: Development of the Fetal Heart . Molecular Development of the
Heart . Role of Peptide Growth Factors in Cardiovascular Development . Fetal and Neonatal Cardiovascular Physiologic
Development . Developmental Electrophysiology in the Fetus and Neonate . Developmental Biology of the Pulmonary
Vasculature . Development of the Pulmonary Circulation: Metabolic Aspects . Development of the Gastrointestinal
Circulation in the Fetus and Newborn . Regulation of the Fetal Cerebral Circulation . Autonomic and Central
Neuroregulation of Fetal Cardiovascular Function . Endocrine Regulation of the Fetal Circulation . Nitric Oxide and the
Perinatal Circulation . Regulation of Umbilical Blood Flow . Fetal and Placental Circulation During Labor .
Cardiovascular Diagnosis in the Fetus and the Effects of Congenital Heart Lesions on Developing Physiology . Response
of the Fetal Circulation to Stress . Fetal and Neonatal Congestive Heart Failure . Physiology of Resuscitation

XIV. The Lung: Normal and Abnormal Structural Development of the Lung . Fetal and Neonatal Lung-liquid Balance .
Functional Development of the Upper Airway . Functional Development of the Lower Airway . Functional Development of
Respiratory Muscles . Mechanics of Breathing . Pulmonary Gas Exchange in the Developing Lung . Oxygen Transport and
Delivery . Control of Breathing in Fetal Life and Onset and Control of Breathing in the Neonate . Pathophysiology of
Apnea of Prematurity . Evaluation of Pulmonary Function in the Neonate . Pathophysiology of Hyaline Membrane Disease
(Excluding Surfactant) . Pathophysiology of Lung Injury and Repair: Special Features of the Immature Lung .
Pathophysiology of Chronic Lung Disease . Physiologic Effects of Conventional Mechanical Ventilation . Physiology of
High Frequency Ventilation . Liquid Ventilation . Physiology of Extracorporeal Membrane Oxygenation

XV. Pulmonary Surfactant: Historical Perspective . Composition of Pulmonary Surfactant Lipids and Proteins .
Biophysical Activities of Pulmonary Surfactant . Lung Morphogenesis: Formation and Function of the Alveolar Surface
Layer . Regulation of Surfactant-associated Phospholipid Synthesis and Secretion . Pathophysiology of Respiratory
Distress Syndrome . Hormonal Therapy for Prevention of Respiratory Distress Syndrome . Surfactant Replacement Therapy

XVI. Physiology Of The Gastrointestinal Tract in the Fetus and Neonate: Cellular and Molecular Aspects of Human
Gastrointestinal Development . Organogenesis, Innervation, and Histologic Development of the Gastrointestinal Tract .
Development of the Enteric Nervous System . Development of Gastric Secretory Function . Development of Intestinal and
Colonic Motility . Motility of the Upper Gastrointestinal Tract in the Fetus and Neonate . Development of Exocrine
Pancreatic Function . Digestive and Absorptive Function in the Fetus and Infant . Pathophysiology of Gastroesophageal
Reflux . Pathophysiology and Epidemiology of Necrotizing Enterocolitis

XVII. Liver and Bilirubin Metabolism: Organogenesis and Histologic Development of the Liver . Fetal and Postnatal
Hepatic Vasculature and Blood Flow . Bile Acid Metabolism during Development . Bile Secretion and its Control in the
Mature and Immature Organism . Hepatic Disposition of Xenobiotics during Prenatal and Early Postnatal Development .
Bilirubin Metabolism and Toxicity in the Newborn . Pathophysiology of Breast-Milk Jaundice . Phototherapy for Neonatal
Jaundice . Pathophysiology of Metabolic Diseases of the Liver . Pathogenesis of Neonatal Cholestasis . Evaluation of
Liver Function

XVIII. The Kidney: Embryogenesis and Anatomic Development of


Key Features
Gain a comprehensive, state-of-the-art understanding of normal and abnormal physiology, and its relationship to disease
in the fetus and newborn premature infant, from Dr. Richard Polin and other acknowledged worldwide leaders in the field.

Understand the implications of fetal and neonatal physiology through chapters devoted to clinical correlation.

New to This Edition
Apply the latest insights on genetic therapy, intrauterine infections, brain protection and neuroimaging, and much more.

Effectively manage the consequences of intrauterine infections with three new chapters covering intrauterine infection
and preterm birth, intrauterine infection and brain injury, and intrauterine infection and chronic lung disease.


Access the complete contents and illustrations online at expertconsult.com - fully searchable!

Published Reviews
"The Third edition of Fetal and Neonatal Physiology represents asubstantial enhancement of the second edition...The
more than 300 contributors are a distinguished group of international scientists and clinicians, well recognized in
their respective fields for their expertise and contributions to perinatal and neonatal medicine. Despite the
multiauthored nature of the book, the chapters flow well and the syle is consistent, for which the editors should be
highly commended...Fetal and Neonatal Physiology is a gold standard reference text that should be on the shelves of
libraries wherever perinatal or neonatal medicine is practiced."
JAMA, July 28, 2004-vol 292,No 4
Author Information
By Richard A. Polin, MD, Professor of Pediatrics, Columbia University College of Physicians and Surgeons; Vice Chairman
for Clinical and Academic Affairs; Director, Division of Neonatology, Morgan Stanley Children's Hospital of New York,
New York, New York; William W. Fox, MD, Professor of Pediatrics, University of Pennsylvania School of Medicine,
Division of Neonatology, Children's Hospital of Philadelphia, Philadelphia, PA and Steven H. Abman, MD, Professor of
Pediatrics, University of Colorado School of Medicine, Division of Pediatric Pulmonary and Critical Care Medicine, The
Children's Hospital, Denver, CO, USA