Biology and Pathology of Trophoblast

Originally published in 2006, this book provides an in-depth account of trophoblast: the tissue derived from the
fertilised egg that nourishes and protects the developing fetus. The cells of the trophoblast have many unique
qualities, and exhibit great variability across different species. It has a fascinating role in the development of the
placenta and as a regulator during early growth of the embryo. These aspects are all fully covered as well as studies
on why it is not rejected by the mother as 'foreign' tissue. Disorders of trophoblast during development also manifest
themselves in several clinical conditions during pregnancy, including gestational trophoblastic disease and pre-
eclampsia. From stem cells through to epigenetics, implantation and X-chromosome inactivation, there is a lot to be
learned about trophoblast, this volume provides a detailed summary of knowledge regarding the subject.


Features
?Covers reproductive immunology, genetics and pathology
?Basic science and clinical aspects dealt with in depth
?Of interest and relevance to all who study the placenta

Table of Contents
Preface Charlie Loke
Chair's introduction Anne McLaren
1. Trophoblast cell fate specification: discussion James Cross
2. Stem cells: pluripotency and extraembryonic differentiation in the mouse Tilo Kunath
3. Epigenetic regulation of trophoblast development P. Hajkova, S. E. Erhardt and M. A. Surani
4. Regulation of X chromosome inactivation in relation to lineage allocation in early mouse embryogenesis Neil
Brockdorff
5. Gestational Trophoblastic disease R. A. Fisher and N. J. Sebire
6. Trophoblast and the first trimester environment Graham J. Burton, Eric Jauniaux
7. Implantation is a sticky situation Olga Genbacev, Akraporn Prakobphol, Russell A. Foulk and Susan J. Fisher
8. Trophoblast regulation of maternal endocrine function and behaviour E. B. Keverne
9. Molecular signalling in embryo-uterine interactions during implantation S. K. Dey and Susanne Tranguch
10.Trophoblast and pre-eclampsia C. W. G. Redman, I. L. Sargent and E. A. Linton
11. Trophoblast and uterine mucosal leukocytes Ashley Moffett
12. Immunology of trophoblast: a reappraisal Charlie Loke.