Assisted Reproductive Technology: Accomplishments and New Horizons

This insightful and thought-provoking 2002 collection of chapters describes the rapid advances that had revolutionised
reproductive medicine in the years leading up to its publication. This transformation was the result of converging and
overlapping developments in reproductive biology, molecular biology and genetics. These advances allied with remarkable
technical developments pushed the boundaries of this discipline ever faster forward. This volume surveys this rapid
expansion as it stood in 2002 and looks ahead at exciting prospects for the future that stand at the watershed between
basic science and clinical application. From oogeneis and spermatogenesis, through to fertilisation, embryogenesis and
cloning, this volume looks at scientific advances. Subsequent chapters focus on infertility and its diagnosis and
treatment using the full armory of assisted reproductive technologies. A concluding section surveys the impact of these
developments on the provision, regulation and financing of reproductive health care in the global community.

Features
?Presents a comprehensive review of the field of ART
?Includes important coverage of future developments and prospects
?Written by leading international authorities


Table of Contents
Foreword Howard W. Jones
Part I. The Gametes: Present and Future: 1. Spermatogenesis in vitro in mammals Bernard J?ou, Charles Pineau and Jorma
Toppari
2. The spermatozoon as a machine J. Travis and Gregory Kopf
3. Attributes of fertile spermatozoa Christopher De Jonge and Christopher L. R. Barratt
4. In vitro oogenesis Frank L. Barnes
5. The oocyte as a machine Kate Hardy
6. Epigenetic influences on human oocyte and embryo development Jonathan Van Blerkom
7. Unresolved and basic problems in assisted reproductive technology Jim Cummins
Part II. Techniques: Present and future: 8. Influences of culture media on embryo development Barry Bavister and Jay
Baltz
9. Cryopreservation of immature and mature gametes John K. Critser, Yuksel Agca and Erik J. Woods
10. Embryonic stem cells Ann M. Lawler and John D. Gearhart
11. Modification of the male genome by gene and spermatogonial transplantation Peter J. Donovan, Michael D. Griswold
and Lonnie D. Russell
12. Genetic diagnosis - the future David Cram and David de Kretser
13. Cloning mammals Don P. Wolf and Shoukhrat Mitalipov
14. Fluorescence imaging: gamete selection and ICSI L. Hewitson, C. Simerly and G. Schatten
Part III. The Clinic: 15. Diagnosis and treatment of male infertility A. Kamischke and E. Nieschlag
16. Tests of male fertility R. John Aitken
17. Diagnosis and treatment for female subfertility Peter Platteau and Paul Devroey
18. Advances in ultrasound imaging Richard P. Dickey and Ellen Matulich
19. The natural cycle vs stimulated cycle Ian D. Cooke
20. Embryo stage and transfer number Alan Trounson
21. The national institutes of health and the research base for improving the outcomes of ART Donna L. Vogel
Part IV. Concepts for the Global Community: 22. From conception to contraception Gustavo F. Doncel, Christine Mauck,
Douglas S. Colvard and Lourens J. D. Zaneveld
23. Developing immunocontraceptives Eileen A. McLaughlin and Michael K. Holland
24. ARTistic license: should assisted reproductive technologies be regulated? Nanette R. Elster
25. Finances and access to ART: justice and publication of results F. Shenfield
26. Sex selection Joe Leigh Simpson and Sandra Ann Carson
27. ICSI: a time bomb? Herman J. Tournaye and Andr?C. Van Steirteghem
28. Cryopreservation of gametes and embryos - legal and ethical aspects Susan M. Avery and Peter R. Brinsden
Index.