Textbook of Pediatric Rheumatology 6/e

Textbook of Pediatric Rheumatology examines the full spectrum of rheumatologic diseases and non-rheumatologic
musculoskeletal disorders in children and adolescents, detailing the presentation, differential diagnosis, course,
management, and prognosis of every major condition. Drs. James T. Cassidy, Ross E. Petty, Ronald M. Laxer, and Carol B.
Lindsley discuss recent developments in diagnosis, treatment, genetics, immunology, imaging, and more. This new edition
features access to the fully searchable text online at www.expertconsult.com, where you'll find a downloadable image
gallery and exclusive web-only content for added value.


Table of Contents
Ch. 1 Introduction to the study of rheumatic diseases in children 2
Ch. 2 Structure and function 9
Ch. 3 The immune system and the inflammatory response 19
Ch. 4 Integrative genomics 64
Ch. 5 Pharmacology and drug therapy 76
Ch. 6 Design, measurement, and analysis of clinical investigations 142
Ch. 7 Assessment of health status, function, and quality of life outcomes : methodology and instruments 174
Ch. 8 A general approach to management of rheumatic diseases in children 184
Ch. 9 Chronic arthritis in childhood 206
Ch. 10 Polyarthritis 261
Ch. 11 Oligoarthritis 274
Ch. 12 Systemic arthritis 291
Ch. 13 Juvenile ankylosing spondylitis 304
Ch. 14 Psoriatic arthritis 324
Ch. 15 Arthropathies of inflammatory bowel disease 334
Ch. 16 Systemic lupus erythematosus 342
Ch. 17 Neonatal lupus erythematosus 392
Ch. 18 Juvenile dermatomyositis 407
Ch. 19 The systemic sclerodermas and related disorders 442
Ch. 20 Localized sclerodermas 470
Ch. 21 Overlap syndromes 482
Ch. 22 Vasculitis and its classification 492
Ch. 23 Leukocytoclastic vasculitis 496
Ch. 24 Polyarteritis nodosa and related vasculitides 512
Ch. 25 Kawasaki disease 521
Ch. 26 Granulomatous vasculitis, giant cell arteritis and sarcoidosis 539
Ch. 27 Behcet's disease 561
Ch. 28 Infectious arthritis and osteomyelitis 568
Ch. 29 Lyme disease 591
Ch. 30 Reactive arthritis 604
Ch. 31 Acute rheumatic fever and post-streptocococcal reactive arthritis 614
Ch. 32 Musculoskeletal manifestations of systemic disease 630
Ch. 33 Immunodeficiencies and the rheumatic diseases 642
Ch. 34 Periodic fever syndromes in children 657
Ch. 35 Cryopyrin-associated periodic syndromes 671
Ch. 36 Noninflammatory musculoskeletal pain conditions 676
Ch. 37 Pain and the pain amplification syndromes 697
Ch. 38 Skeletal maturation and bone mineralization in the pediatric rheumatic diseases 716
Ch. 39 Skeletal malignancies and related disorders 728
Ch. 40 Primary disorders of bone and connective tissues 744