Reproductive Endocrinology and Infertility

Management of the modern reproductive endocrinology and infertility clinic has become very complex. In addition to the
medical and scientific aspects, it is crucial that the modern director be aware of of incongruent fields such as
marketing, accounting, management, and regulatory issues. Reproductive Endocrinology and Infertility: Integrating
Modern Clinical and Laboratory Practice was developed to assist the practicing reproductive endocrinologist and/or
laboratory director by providing an overview of relevant scientific, medical, and management issues in a single volume.
Experts in all pertinent areas present concise, practical, evidence-based summaries of relevant topics, producing a key
resource for physicians and scientists engaged in this exciting field of medicine. As novel technologies continue to
amplify, Reproductive Endocrinology and Infertility: Integrating Modern Clinical and Laboratory Practice offers insight
into development, and imparts extra confidence to practitioners in handling the many demands presented by their work.

Keywords ?Artificial Insemination - In-Vitro Fertilization - Infertility - Ovarian Hyperstimulation Syndrome -
Polycystic Ovary Syndrome - Reproductive Technology - Varicocele

Related subjects ?Gynecology - Internal Medicine - Urology


Part I Management of the R.E.I. Clinic and Laboratories
1 Characteristics of a Successful R.E.I. Clinic and Laboratory ............................. 3
Douglas T. Carrell and C. Matthew Peterson
2 Assisted Reproductive Technology Practice Management ................................... 7
C. Matthew Peterson, Ahmad O. Hammoud, Erika Lindley,
Douglas T. Carrell, and Karen Wilson
3 Collaboration Within the Reproductive Endocrinology
and Infertility Practice: Integration of Laboratory
and Clinic Operations .............................................................................................. 39
Vincent W. Aoki and Douglas T. Carrell
4 Informed Consent in Advanced Reproductive Technology .................................. 43
Kirtly Parker Jones
5 Reproductive Laboratory Regulations, Certifi cations and
Reporting Systems ................................................................................................... 55
Brooks A. Keel and Tammie K. Schalue
6 Successfully Integrating the FDA Regulations into Your Practice ...................... 71
Wendy D. Latash
7 Psychosocial Consequences of Infertility and Treatment ..................................... 93
Lone Schmidt
8 A Live Baby or Your Money Back: The Marketing of In Vitro
Fertilization Procedures .......................................................................................... 101
David C. Schmittlein and Donald G. Morrison
Part II Female Reproductive Physiology and Medicine
9 Ovulation: A Molecular View.................................................................................. 119
Mats Br?nstr?, Anna Karin Lind, and Pernilla Dahm-K?ler
10 Clinical Evaluation of Female Factor Infertility ................................................... 133
Yulian Zhao, Lisa Kolp, Melissa Yates, and Howard Zacur
11 Polycystic Ovary Syndrome .................................................................................... 147
Catherine J. Wheeler, William R. Keye, and C. Matthew Peterson
12 The Current Status for Metformin Use in Reproductive Medicine .................... 183
Richard S. Legro
13 Clinical Aspects of Endometriosis .......................................................................... 191
Attila Bokor, Christel Meuleman, and Thomas D묱ooghe
Contents
x Contents
14 Common Endocrinopathies in Reproductive Endocrinology .............................. 209
Shawn Gurtcheff and C. Matthew Peterson
15 Acquired Uterine Factors and Infertility ............................................................... 235
Harry H. Hatasaka
16 M?lerian (Paramesonephric) Anomalies and Associated
Wolffi an (Mesonephric) Duct Malformations ....................................................... 265
Jessie Dorais and C. Matthew Peterson
17 Recurrent Miscarriage ............................................................................................
281
D. Ware Branch and Cara Heuser
18 Laparoscopy in the Diagnosis and Treatment of Female Infertility .................... 297
Howard T. Sharp and Johnny Yi
19 Turner
Syndrome ..................................................................................................... 307
Carolyn A. Bondy
20 Errors in Chromosome Segregation During Oogenesis
and Early Embryogenesis ........................................................................................ 325
Maj Hult?, Edward Smith, and Joy Delhanty
Part III Male Reproductive Physiology and Medicine
21 An Overview of Sperm Production ........................................................................ 345
Louis Hermo and Bernard Robaire
22 Meiotic Recombination and Errors During Spermatogenesis ............................. 357
Helen Ghislaine Tempest and Renee Halo Martin
23 Clinical Evaluation and Treatment of Male Factor Infertility............................. 367
Michael A. Poch and Mark Sigman
24 Semen Analysis: Essentials for the Clinician ......................................................... 379
Lars Bj?ndahl
25 Sperm Capacitation, the Acrosome Reaction, and Fertilization.......................... 389
Peter Sutovsky
26 Advanced Tests of Sperm Function ........................................................................ 423
Joseph P. Alukal and Dolores J. Lamb
27 Genetic Testing of Male Infertility .......................................................................... 431
Csilla Krausz
28 Varicocele and Male Infertility ............................................................................... 445
Cigdem Tanrikut and Peter N. Schlegel
29 Sperm Retrieval Techniques ................................................................................... 453
Paul J. Turek
30 The Clinical Utility of the Evaluation of Sperm Chromatin ................................ 467
Sergey I. Moskovtsev and Brendan M. Mullen
Part IV Assisted Reproductive Therapies: Artifi cial Insemination
31 Artifi cial Insemination: Intrauterine Insemination .............................................. 487
Pieternel Steures, Ben W.J. Mol, and Fulco van der Veen
32 Sperm Preparation for Artifi cial Insemination ..................................................... 497
Greg L. Christensen
Contents xi
33 Sperm Banking, Donation, and Transport in the Age
of Assisted Reproduction: Federal and State Regulation ..................................... 509
Grace M. Centola
34 Reproductive Treatment of HIV-1 Discordant Couples ....................................... 517
Valeria Savasi and Enrico Ferrazzi
35 Ovulation
Induction ................................................................................................. 525
Mark Gibson
36 Transvaginal Sonography in Reproductive Endocrinology
and
Infertility ...........................................................................................................
545
Anne Kennedy and C. Matthew Peterson
Part V Assisted Reproductive Therapy: In Vitro Fertilization
37 Establishing the IVF Laboratory: A Systems View .............................................. 569
Antonia V. Gilligan
38 Preparation and Selection of Sperm for IVF and ICSI ........................................ 579
Charles L. Bormann, Jose R. Alagretti, Eduardo L.A. da Motta,
Paulo Serafi ni, and Gary D. Smith
39 The Genetic and Epigenetic Contributions of Sperm
to Early Embryogenesis ........................................................................................... 591
Denny Sakkas, Maria Lalioti, Hasan M. El-Fakahany, and Emre Seli
40 Micromanipulation of Human Oocytes and Embryos:
Applications of Intracytoplasmic Sperm Injection
and Assisted Hatching in Infertility Treatment ..................................................... 601
Kenneth I. Aston and Klaus E. Weimer
41 Embryo Culture Techniques ................................................................................... 613
Katharine V. Jackson and Catherine Racowsky
42 In-Vitro Maturation of Human Oocytes ................................................................ 633
Ezgi Demirtas, Hananel Holzer, Weon-Young SON, Ri-Cheng Chain,
and Seang Lin Tan
43 Integrating Preimplantation Genetic Diagnosis
into the ART Laboratory ......................................................................................... 647
Kenneth C. Drury
44 Evaluation and Selection of Preimplantation Embryos
for
Transfer ...............................................................................................................
663
Lynette Scott
45 Embryo Transfer in IVF: Evidence-Based Clinical Practice ............................... 677
Lindsay Mains and Bradley J. Van Voorhis
46 Cryopreservation of Human Oocytes and Embryos ............................................. 689
Barry Behr and Yimin Shu
47 Preserving
Fertility .................................................................................................. 703
Kutluk Oktay and Ozgur Oktem
48 Ovarian Hyperstimulation Syndrome .................................................................... 711
Kenneth H.H. Wong
49 Pregnancy Outcomes in Infertile Couples ............................................................. 715
Caroline Signore and Uma M. Reddy
xii Contents
50 The Impact of Complementary Medicine on In Vitro Fertilization .................... 727
Laurence C. Udoff and Grant Zhang
Part VI Research in the REI Practice and Laboratories
51 Designing a Clinical Research Infrastructure ....................................................... 741
Tonya Edvalson, Emily Hixson, and Michael Varner
52 Integrating Research into a Clinical Practice........................................................ 751
Douglas T. Carrell
53 Research Regulations: The Role of the Institutional Review Board ................... 757
Benjamin R. Emery and Mark A. Munger
54 Technology Transfer and Its Role in the Practice
of Reproductive Endocrinology and Infertility ..................................................... 763
Ashley J. Stevens
55 The Environment and Reproduction: Endocrine Disruption,
Reproductive Impairment, and Epigenetics .......................................................... 781
C. Matthew Peterson, Douglas T. Carrell, Michael Varner,
Joseph Stanford, Mary Croughan, and Germaine Buck Louis
Index ..................................................................................................................
............... 805