Perinatal Programming: Early Life Determinants of Adult Health and Disease

Table of Contents
Foreword
Preface
1 The role of the mother, placenta, and fetus in the control of fetal growth during human pregnancy 3
2 Maternal nutrition and later disease risk 17
3 Prenatal stress influences human fetal development and birth outcomes : implications for development origins of
health and disease 29
4 Prenatal glucocorticoid exposure and adult pathophysiology 49
5 Neuroendocrine programming of adult disease : current perspectives and future directions 61
6 Prenatal programming of postnatal obesity 73
7 Programming the fetal pancreatic axes 85
8 Perinatal programming of metabolic homeostasis 97
9 Development of domestic animal models for the study of the ontogeny of human disease 117
10 Prenatal influences on immunity and the developmental trajectory of infant primates 131
11 Role of prenatal events in the development of allergic disease 143
12 Perinatal characteristics and asthma and allergies in offspring 155
13 Maternal alcohol consumption and neuroendocrine-immune interactions in the offspring 169
14 The 'old friends' hypothesis : how early contact with certain microorganisms may influence immunoregulatory circuits
183
15 Long-term effects of repetitive pain in the neonatal period : neuronal vulnerability, imprinting, and plasticity 197
16 Pain sensitivity during ontogeny and long-term effects of prenatal noxious events 211
17 Prenatal androgens and the ontogeny of behavior 225
18 The role of prenatal stress in the programming of behavior 241
19 Antenatal programming of child behavior and neurodevelopment : links with maternal stress and anxiety 253
20 Cytokines, social development, and psychopathology : an empirical and theoretical integration 267
21 Genomic imprinting and epigenetic programming of fetal development 289
22 Maternal programming of glucocorticoid receptor expression and HPA responses to stress through DNA methylation in
the rat 309