Opioids Medicine : A comprehensive review on the mode of action and the use of analgesics in different clinical pain states (Hardcover)

Introduction. Part I Rational for the Use of Opioids in Nociceptive Transmission. The Nociceptive System, an Elementary
Part of the Body뭩 Protective Scheme. Acute Pain ?Sequence of Changes in the Body. Differences in Pain Quality.
Anatomy of Pain and Analgesia. Significance of C-Fibers in Pain Transmission. Significance of A?Fibers in Pain
Modulation. Transmission of Pain with Different Qualities. Substance P, a Mediator of Pain and a Member of the
Tachykinine Family. Supraspinal Processing of Pain. Transduction of Nociception Via the Spinothalamic Tracts. The
Descending Antinociceptive System. Neurophysiology of Pain ?Type of Receptor Sites Involved in Therapy. Transduction
of Nociceptive Afferences Via Ascending Pathways. Different Therapeutic Approaches in Pain Therapy. Significance of
Bradykinins in Inflammatory Pain. Cox Inhibitors in the Alleviation of Pain. The Opioid Receptor System ?Main Target
in Pain Therapy. Inhibitory and Excitatory Effects of Nociception at the Spinal Cord Level. Neurohormones In
Transmission of Nociception. Melanocortins. Cholecystokinins. Calcitonin-Gene-Related Neuropeptide. Galanin. Nitric
Monoxide, Mediator for Chronic Pain. The Cannabinoid System. Ion Channel Modulators Resulting in
Facilitation/Inhibition of Nociception. The P2X and P2Y Receptor System. The Vanilloid Receptor System. Voltage-Gated
Sodium Channels as Ion Conduit Modulators. Non Voltage-Gated Potassium Channels. Ionotropic Glutamate Receptor Ion
Channel Modulators. Excitatory Glutamate Receptor; Mediator of Pronociceptive Effects. The Nicotinic/Acetylcholine
(NAchR) Receptors. Nerve Growth Factor (NGF) in Mediating Hyperalgesia. Significance of the Immune System and Microglia
in Chronic Pain. Reflectory, Segmental Mediation of Pain Afferents. Sequence of Resulting in Neuropathic Pain. Causes
of Potentiation and Transition From Acute to Chronic Pain. Neurophysiological Changes Taking Effect During Evolution of
Pain. Supraspinal Engrams Relevant in Transition from Acute to Chronic Pain. Preventing Transition from Acute to
Chronic Pain ?Use of Analgesics with Different pharmacology. Rationale for the Use of Opioids. Reasons for
Insufficient Opioid use ?The 11 Myths in Opioid Therapy. Alternative Therapeutic Targets in Pain Therapy. Proton
Channels as Therapeutic Targets in Pain Therapy. Adjuvant Analgesics in Pain Therapy. Difference in Receptor
Activation/Inhibition as Drug Targets. Mechanism of Action of Tricyclic Antidepressants. Pharmacologically Resistant ?
Psychologically Conditioned Pain. The Malingering Patient with Compensatory Pain Behavior. References. Part II
Mechanism of Action of Opioids and Clinical Effects. Conversion of Morphine to Heroin (Diacetylmorphine). Major Classes
of Opioid Analgesics in Clinical Practice. Mode of Action of Opiates/Opioids. Overview of the Different Opioid
Receptors and their Subtypes. Agonists, Antagonists, their Potency and Mode of Action. Relative Potency and
Equianalgesic Doses. Specific Binding Sites for Opioids in the CNS. Reasons for Difference in Potency of Opioids.
Intracellular Signaling Following Opioid Binding. G-Protein Coupled Receptors and the Adenylate Cyclase Signaling
System, Mediators of Opioid Action. Significance of the Heterotrimeric G-Proteins in Intracellular Transmission.
Differences in Clinical Effects of Various Opioids. Opioid-Refractory Painful Conditions. Opioid-Related Side Effects.
Opioid-Induced Respiratory Depression. Significance of the Different Opioid Receptors in the Mediation of Respiratory
Depression. Vigilance, Leading Parameter in Opioid-Related Respiratory Depression. Reasons for Prolongation of Opioid-
Related Respiratory Depression in Patients. Difference in Sedative-Hypnotic Effect of Opioids. Difference in the
Hypnosedative and Analgesic Effect of Potent Opioids. Potential Epileptogenic Potency of Opioids. The Antitussive
Action of Opioids (Blockade of Cough Reflex). Dependence Liability of Opioids ?Pharmacological Principles of
Addiction. Neurobiological Changes with Addiction. Opioids Inducing Nausea and Emesis. Opioids and Muscular Rigidity.
The Pupillary Effect of Opioids. Opioids and Gastrointestinal Inhibition (Constipation). Clinical Relevance of Opioid-
Induced Constipation. Opioids and the Cardiovascular System. References. Part III Opioids, an Integrative Part in
Perioperative Medicine. Intraoperative Use of Opioids for Anesthesia. Potentiation of Opioid-Based Anesthesia.
Pharmacokinetics of Opioids: Significance for Clinical Use in Anesthesia. Significance of Pharmacokinetic Data for
Practical Use. Advantages of "Maintenance Phase" Infusions Compared to Intermittent Bolus Dose. Use of Target
Controlled Infusion (TCI) Systems in Anesthesia. "On-Top"-Dose of Either Alfentanil or Remifentanil in an Opioid-Based
Anesthetic Regimen. Recommendations for the Use of Remifentanil. The Pharmacology of Sufentanil. Respiratory Depression
After Sufentanil. The Hypnosedative Effect of Sufentanil. Sufentanil and Muscular Rigidity. Sufentanil in Selective
Operations. Neurosurgery. Sufentanil in Open-Heart Surgery. Interaction of Sufentanil. Volatile Aspects. Muscle
Relaxants. Barbiturates. Practical Considerations for the Use of Sufentanil. Examples for the Use of Sufentanil in
Anesthesia. Opioids for Use in Postoperative Pain Management. Addiction Liability by Use of Opioids for Postoperative
Pain. Time-Contingent Dosing of Opioids for Postoperative Pain. Selection of the Appropriate Agent in Postoperative
Pain Management. Choice of Opioid Agents for Post-Operative Pain Treatment. Dosage of Opioid Analgesics in Post-
Operative Pain Treatment. Implications of Agonist/Antagonists in Postoperative Pain Management. Patient-Controlled
Analgesia (PCA) for Postoperative Pain Therapy. Opioids On-Demand, Without Use of a PCA System. New Techniques for
Postoperative Pain Management. Selective Opioid Antagonists for Postoperative Reversal of Opioid Side Effects.
Postoperative Opioids ?Summary and Outlook. Neuraxial Administration of Opioids for Pain Therapy. Side Effects of
Epidural Opioids. Lipophilic or Hydrophilic Opioids for Neuraxial Use. Extended-Release Epidural Morphine for
Postoperative Pain. Combination of an Epidural Opioid with a Local Anesthetic. Continuous-Infusion Epidural Analgesia
(CIEA). Intrathecal Use of Opioids. Mixed Agonist/Antagonists and _2-Agonists for Neuraxial Use. References. Part IV
Use of Potent Opioids for Chronic Pain Management. Long-Term Management of Chronic Pain. Defining the Different Type of
Opioids. Agonists. Antagonists. Mixed Agonist뺸ntagonists. The WHO Guidelines for Pain Therapy. Dosing of Opioids in
Tumor Pain. Co-Analgesics (Adjuvants) for Long-Term Pain Therapy with Opioids. Buprenorphine ?Opioid with Unique
Receptor Kinetics for Chronic Pain. Transdermal Patches for Use in Chronic Pain ?Fentanyl TTS and Buprenorphine TDS.
Rational for the Use of Transdermal Systems. Pharmacokinetics of Opioids Used in Transdermal Systems. Specificity of
Transdermal Buprenorphine. Oral Transmucosal Fentanyl Citrate (OTFC) Stick for Treatment of Breakthrough Pain.
Differences in Transdermal Technology and Pharmacology of Fentanyl and Buprenorphine. Change from Oral Morphine to a
Transdermal Opioid. Rotation from Oral Morphine to Transdermal Buprenorphine. Commonly Observed Side-Effects in Long-
Term Pain Treatment with Opioids. Respiratory Depression. Development of Dependency in Chronic Opioid Use. Development
of Tolerance During Long-Term Use of Opioids. Constipation, a Common Side Effect of Opioids. Nausea and Vomiting.
Marked Sedation. Pruritus. Rotation from One Opioid to Another. Opioid Rotation from Morphine to Buprenorphine or
Methadone. Oxycodone and Hydromorphone ?Alternative Opioids for Pain Relief. Use of Opioids in Non-malignant Pain.
Driving Ability While Taking an Opioid for Pain Relief. New Options in Opioid Medication ?The OROS?(Oral Osmotic
Pump) System. Oxytrex?Ultra-Low Dose Opioid Antagonist Combined with Oxycodone with Less Tolerance Development. Remoxy
?with ORADUR Technology, Opioid with an Abuse-Resistant Formulation. Combining Oxycodone with the Opioid Antagonist
Naloxone to Deter from Drug Abuse. Delivery of Opioids via the Lungs ?The Aerosolized Liposome- Encapsulated Fentanyl
(AeroLEF?. AERx?Pulmonary Delivery System for Morphine and Fentanyl. DUROS?Implant Technology for Chronic Pain
Treatment. Transdur?Sufentanil Technology with 1 Week of Opioid Release. Effervescent Buccal Fentanyl Tablet for
Treatment of Breakthrough Pain. Intrathecal DUROS?Opioid Delivery Using a Precision Miniature Catheter. Appendices:
Duration of Action and Dosing of Opioid Analgesics. References. Part V Detection of Illicit Use of Opioids in Primary
Care. Introduction. Physical Dependency. Definitions and Concepts in Physical Dependency. Terminology in Illicit Use of
Opioids. Bioavailability of Pain Medicine Related to Abuse. Avoiding Abuse Liability When Prescribing Opioids. Avoiding
Illicit Use by Ongoing Assessment and Documentation. Typical Drug Scams to Obtain a Prescription Opioid. Prescribing
Opioids ?The Controlled Substances Act from 1979. Typical Patterns as Predictive Signs of Aberrant Drug-Related
Behavior. Avoiding Drug Diversion from Medical to Illicit Use. Avoiding Illicit Use by Combining Opioids with
Antidepressants/Antiepileptics. Demask the Patient Prone to Develop Illicit Use. Further Stigma of Persons with a
Potential Drug Addictive Behavior Pattern. The Alcohol Addictive Patient. The Most Common Signs of Alcohol Addiction.
Concomitant Sequelae of Alcoholism. Common Comprehensions on Prescription Drug Abuse. Physical Signs and Symptoms of
Hard Drug Abuse. The Red Flags During Initial Assessment. Use of Urine Drug Screening (UDS). Summary of Considerations
When Using Urine Drug Screening (UDS). Indications for Random Urine Drug Testing. Types of Urine Drug Testing. Summary
When Using Urine Drug Testing (UDT). Interpretation of UDT Results. Limitations of Urine Drug Testing (UDT). Half-Life
of Detection and Cut-Offs in Urine Drug Screening. Interpretation of Results. Pitfalls with Urine-Drug-Testing (UDT).
Summary of Considerations When Having a Positive Urine Test. Test Procedure When Using a Multi-Test Card. Confirmation
Analysis of Quick Tests. Assessing Possible Manipulation of the Urine Sample. Screening for Alcohol Abuse. Hair or
Saliva for Drug Testing. Hair Analysis for the Detection of Abused Drugs and Medications. References. Index.
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