Fetal Medicine-2판

Foreword
Preface
Contributors
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Sect. 1 Cell, Molecular and Reproductive Biology
1 Early Concepts and Terminology 3
2 Genomic Imprinting 7
3 Staging Embryos in Development 15
4 Embryonic Tissues 23
5 Cellular Mechanisms in Development 41
6 Homeobox Genes and Determination of Embryonic Body Plan 49
7 Embryology of left-right: Defects of Situs in the Embryo 59
8 Development of the Head 67
Sect. 2 Fetal and Placental Physiology
9 Implantation 87
10 Development of the Placenta and its Circulation 93
11 Placental Function in Maternofetal Exchange 111
12 Fetal Growth and its Regulation 127
13 Development of the Cardiovascular System 141
14 Kidney and Urinary Tract 155
15 Amniotic and Fetal Fluids 173
16 Lung Development and Maturation 181
17 Fetal Endocrinology 197
18 Blood and Immune System 207
19 Myometrial Physiology and Parturition 221
20 Maturation of the Brain and Behavioural States 235
21 The Response of the Fetal Brain to Asphyxia/Ischaemia 241
Sect. 3 Ethical Issues
22 Ethical Issues in Maternal - Fetal Medicine 265
Sect. 4 Epidemiology
23 Primary Prevention of Neural Tube Defects 283
24 Application of Epidemiology to Fetal Medicine 291
25 Assessing the Organisation and Effect of Perinatal Care 299
26 Adult Consequences of Fetal Disease 309
27 Fetal Malformation Registers 317
Sect. 5 Prenatal Screening and Diagnosis
28 Genetics and Post-Pregnancy Counselling 327
29 The Stresses of Prenatal Screening and Diagnosis 333
30 Termination of Pregnancy: Methods, Safety and Recent Developments 341
31 Bereavement and Reaction to Fetal Loss 349
32 Screening for Genetic Disease in the Community 359
33 Biochemical Screening for Neural Tube Defects and Down Syndrome 373
34 Ultrasound Screening for Fetal Abnormalities 389
35 Fetal Cells in the Maternal Circulation 409
36 Invasive Diagnostic Methods 417
37 Trends in Cytogenetics 435
38 DNA Analysis 453
39 Preimplantation Genetic Diagnosis 465
40 Transcervical Fetal Cells 473
Sect. 6 Diagnosis of Fetal Genetic Diseases
41 Haemoglobinopathies 483
42 Prenatal Diagnosis of Haemophilia and other Allied Disorders 499
43 Cystic Fibrosis 513
44 Muscular Dystrophies 519
45 Inborn Errors of Metabolism 525
46 Genodermatoses 545
Sect. 7 Diagnosis and Management of Fetal Malformations
47 Second Trimester Sonographic Features of Aneuploidy 553
48 Fetal Nuchal Translucency at 10-14 weeks of Gestation 573
49 First Trimester Diagnosis of Fetal Malformations 581
50 Craniospinal and Central Nervous System Defects 599
51 Diagnosis and Management of Fetal Heart Disease 641
52 Thoracic Malformations 651
53 Kidney and Urinary Tract Disorders 665
54 Gastrointestinal Abnormalities 703
55 Skeletal Anomalies 715
56 Fetal Hydrops and Tumours 737
57 Operative Fetoscopy 755
Sect. 8 Diagnosis and Management of other Fetal Conditions
58 The Management of Intrauterine Growth Restriction 773
59 Red Cell Alloimmunisation 785
60 Diagnosis and Management of Fetal Platelet Disorders 805
61 Fetal Cardiac Arrhythmias 817
62 Fetal Endocrine Disorders 829
63 Early Pregnancy Loss 835
64 Fetal Infection 849
65 Twins and Polyhydramnios 863
66 Termination of Multifetal Pregnancy Reduction and Selective Pregnancies 879
67 In Utero Haematopoietic Stem Cell Transplantation 887
68 Fetal Gene Therapy 899
Sect. 9 Methods of Fetal Monitoring
69 Antenatal Cardiotocography 909
70 Biophysical Activity 919
71 Fetal Biometry 939
72 Doppler Ultrasonography 955
73 Day Assessment Units 967
74 Admission and Stimulation Tests in Labour 977
75 Intrapartum Fetal Monitoring: CTG, ECG and Fetal Blood Sampling 985
76 New Optical Methods of Intrapartum Fetal Surveillance 1005
77 The Postmortem 1017
Sect. 10 The Neonate
78 Adaptation and Outcomes: the Neonatal Interface with Fetal Medicine 1039
79 Cardiorespiratory Adaptation to Extrauterine Life 1045
80 Thermal Adaptation to Extrauterine Life 1053
81 Metabolic Adaptation to Extrauterine Life 1059
82 The Contribution of Preterm Birth to Outcomes in Children 1071
83 The Contribution of Perinatal Asphyxia in the Term Infant to Outcomes in Children 1087
App Charts of Fetal Measurements 1095
Index 1141