Multiple Sclerosis - A Comprehensive Text

Section I: Multiple sclerosis: history and clinical manifestations:
History of multiple sclerosis. Clinical features of multiple sclerosis. Unusual presentations and
variants of ideopathic central nervous system demyelinating diseases. Paediatric multiple
sclerosis. Diagnosis of multiple sclerosis. Neuroimaging in multiple sclerosis. Cerebrospinal fluid
analysis in multiple sclerosis. Natural history of multiple sclerosis. Epidemiology of multiple
sclerosis. Clinical neurophysiology of multiple sclerosis.
Section II: Multiple sclerosis: pathophysiology and biology:
Neuropathology of multiple sclerosis. Neurophysiology of demyelination. Immunology of multiple
sclerosis. Genetics of multiple sclerosis. Infectious agents and multiple sclerosis. Models of
chronic relapsing experimental autoimmune encaphalomyelitis. Genetic manipulatuions of experimental
autoimmune encephalomyelitis in the mouse. Biology of myelin. New tools for investigating the
immunopathogenesis of multiple sclerosis.
Section III: Multiple sclerosis: tretment and prospects:
Immunomodulatory therapy: critical appraisal of trial results and marketing claims. Treatment of
multiple sclerosis with disease-modifying therapies. Escape therapies and management of multiple
sclerosis. Novel and promising therapeutic stratgies for multiple sclerosis. Moving towards
remyelinating and neuroprotective therapies in multiple sclerosis. Symptomatic therpaies for
multiple sclerosis. Bladder and sexual dysfunction in multiple sclerosis. Neuropsychological
aspects of multiple sclerosis. Rehabilitations of multiple sclerosis. Design and analysis of
clinical trials in multiple sclerosis. Role of data monitoring committees in multiple sclerosis
clinical trials. Outcome measures in multiple sclerosis.