Biology and Pathology of Trophoblast

This is the first dedicated, in-depth account of trophoblast: the
tissue derived from the fertilized egg that nourishes and protects
the developing fetus. The cells of the trophoblast have many unique
qualities, and exhibit great variability across different species. It
has a fascinating role in the development of the placenta and as a
regulator during early growth of the embryo. These aspects are all
fully covered as well as studies on why it is not rejected by the
mother as 'foreign' tissue. This volume provides an up-to-date
summary of the state of current knowledge and offers some glimpses as
to future development on the scientific and clinical front.


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Contents

Preface Charlie Loke
Chair's introduction Anne McLaren
1. Trophoblast cell fate specification: discussion James Cross
2. Stem cells: pluripotency and extraembryonic differentiation in the
mouse Tilo Kunath
3. Epigenetic regulation of trophoblast development P. Hajkova, S. E.
Erhardt and M. A. Surani
4. Regulation of X chromosome inactivation in relation to lineage
allocation in early mouse embryogenesis Neil Brockdorff
5. Gestational Trophoblastic disease R. A. Fisher and N. J. Sebire
6. Trophoblast and the first trimester environment Graham J. Burton,
Eric Jauniaux
7. Implantation is a sticky situation Olga Genbacev, Akraporn
Prakobphol, Russell A. Foulk and Susan J. Fisher
8. Trophoblast regulation of maternal endocrine function and
behaviour E. B. Keverne
9. Molecular signalling in embryo-uterine interactions during
implantation S. K. Dey and Susanne Tranguch 10.Trophoblast and pre-
eclampsia C. W. G. Redman, I. L. Sargent and E. A. Linton
11. Trophoblast and uterine mucosal leukocytes Ashley Moffett
12. Immunology of trophoblast: a reappraisal Charlie Loke.