In Vitro Maturation of Human Oocytes:Basic Science to Clinical Applications

The use of IVM in assisted reproductive technology continues to
increase around the world. The major benefit of IVM is that
significant numbers of oocytes can be collected from ovaries without
recourse to ovarian stimulation. This reduces the costs, time, and
risks associated with conventional IVF. Although initially limited to
women with polycystic ovary syndrome who were at higher risk of
problems following ovarian stimulation, IVM is increasingly used in
women with normal ovulatory menstrual cycles. This authoritative text
covers the current scientific knowledge of oocyte development and the
understanding behind the techniques involved in the clinical
application of IVM in assisted reproductive technologies.


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Section 1: 1. Oocyte Growth in the Ovary 2. Interaction of Oocytes
and Somatic Cells 3. In-Vitro Development of Small Ovarian Follicles
4. Mechanism of Oocyte Maturation 5. Gene Expression during Oocyte
Maturation 6. Epigenetic Modification during Oocyte Maturation 7.
Maturation of Primordial Follicles ?the Next Step Section 2: 8.
Polycystic Ovaries and Polycystic Ovary Syndrome 9. Clinical Aspects
of Polycystic Ovary Syndrome 10. Prediction and Prevention of Ovarian
Hyperstimulation Syndrome 11. Clinical Problems Associated with
Ovarian Stimulation (Excluding OHSS) Section 3: 12. IVM for the
Treatment of Infertility with PCOS 13. The First Steps on the Era of
IVM 14. FSH Priming in IVM Cycles 15. Combination of FSH and hCG
Priming in IVM Cycles 16. IVM Oocyte Collection ?Similarities and
Differences with IVF 17. Endometrial Preparation for IVM 18.
Laboratory Aspects of IVM 19. Follow-Up of Children Born after IVM
Section 4: 20. How Do We Improve Implantation Rate Following IVM? 21.
Maturation of Immature Oocytes in Stimulated Cycles 22. IVM as an
Alternative for Poor Responders 23. IVM as an Alternative for Over-
Responders 24. Combination of Natural Cycle IVF with IVM 25. IVM for
Fertility Preservation Bibliographies and Index