Molecular Oncology of Breast Cancer

Jeffrey S. Ross, M.D., Albany Medical College, Gabriel N. Hortobagyi,
MD, FACP, The University of Texas M. D. Anderson Cancer Center
The first comprehensive reference to focus on the molecular
development and treatment of the disease, Molecular Oncology of
Breast Cancer provides authoritative information across the spectrum
of modern breast cancer research and clinical care. Edited by two
world-class experts in cancer pathology, drug development, and
patient management, with contributions from over 50 experts, this
ground-breaking text describes the genes, proteins, and biologic
pathways that are being evaluated today and will be tested in the
future to derive the molecular signature of each newly diagnosed
breast cancer. For the first time, readers can now obtain, in a
single volume, up-to-date information on how molecular-based tests
are being used to identify predisposition, provide earliest
detection, decide classification based on genetic fingerprint and
predict therapy-specific outcomes. MOBC includes unique chapters on
functional imaging and the impact of targeted therapies on the FDA
approval process. This book gives readers vital, up-to-date
information on important molecular discoveries that affect the
everyday management of the breast cancer patient.

Molecular Oncology of Breast Cancer
Jeffrey S. Ross, M.D., Albany Medical College, Gabriel N. Hortobagyi,
MD, FACP, The University of Texas M. D. Anderson Cancer Center

Foreword: John Mendelsohn, MD, President, The University of Texas M.
D. Anderson Cancer Center

Preface: Gabriel N. Hortobagyi, MD, FACP, University of Texas M. D.
Anderson Cancer Center, Houston, TX and Jeffrey S. Ross, MD, Albany
Medical College, Albany, NY and Millennium Pharmaceuticals, Inc.,
Cambridge, MA

Chapter 1. Introduction and Background

Gabriel N. Hortobagyi, MD, FACP, The University of Texas M. D.
Anderson Cancer Center, Houston, TX

Chapter 2. Molecular Diagnostic Techniques in Breast Cancer

Jeffrey S. Ross, MD, Albany Medical College, Albany, NY and
Millennium Pharmaceuticals, Inc., Cambridge, MA

Chapter 3. Clinical and Molecular Epidemiology of Breast Cancer

Abenaa Brewster, MD, MHS, The University of Texas M. D. Anderson
Cancer Center, Houston, TX
Melissa Bondy, PhD, both of The University of Texas M. D. Anderson
Cancer Center, Houston, TX

Chapter 4. Predisposition for Breast Cancer

Marion Kiechle, MD, Technical University of Munich, Munich, Germany
Alfons Meindl, PhD, Technical University of Munich, Munich, Germany

Chapter 5. Screening and Early Detection, Serum and Nipple
Aspirates, Routine and Molecular Methods including Reverse
Transcriptase-Polymerase Chain Reaction, and Proteomics

Douglas P. Malinowski, PhD, Tripath Oncology, Durhasm, NC

Chapter 6. Genomic and Molecular Classification of Breast Cancer

Christos Sotiriou, MD, Jules Bordet Institute, Free University of
Brussels, Belgium
Christine Desmedt, PhD, Jules Bordet Institute, Free University of
Brussels, Belgium
Virginie Durbecq, PhD, Jules Bordet Institute, Free University of
Brussels, Belgium
Lissandra Dal Lago, MD, Jules Bordet Institute, Free University of
Brussels, Belgium
Marc Lacroix, PhD, Jules Bordet Institute, Free University of
Brussels, Belgium
Fatima Cardoso, MD, Jules Bordet Institute, Free University of
Brussels, Belgium
Martine Piccart, MD, PhD, Jules Bordet Institute, Free University of
Brussels, Belgium

Chapter 7. Cytology: Clinical Sample Procurement and On-Slide
Technologies

W. Fraser Symmans, MD, The University of Texas M. D. Anderson Cancer
Center, Houston, TX

Chapter 8. Histopathology of Breast Cancer: Correlation With
Molecular Markers

W. Fraser Symmans, MD, The University of Texas M. D. Anderson Cancer
Center, Houston, TX

Chapter 9. Sentinel Lymph Node Dissection and Micrometastasis
Detection in Bone Marrow and Lymph Nodes

Volkmar M