Hemostasis And Thrombosis: Basic Principles And Clinical Practice

Hardbound. The welfare of laboratory animals, as well as the ethical
issues involved in the humane use of animals for scientific purposes,
are discussed in this new revised edition. Information is included on
the biology and husbandry of animal models; on behavior, stress and
well-being; genetic and microbiological standardization; health
monitoring; anaesthesiology; animal alternatives; ethics.This book
addresses all of the aspects that scientists need to know when
considering the design of an animal experiment. Replacement,
reduction and refinement of animal experiments are the guiding
principles for its contents.

Overview of hemostasis 3
Overview of coagulation, fibrinolysis, and their regulation 17
The blood coagulation factors : their complementary DNAs, genes, and
expression 21
Genetics of coagulation 59
Tissue factor structure and function 91
Contact activation (Kallikrein-Kinin) pathway : multiple physiologic
and pathophysiologic activities 107
Molecular and structural biology of factor IX 131
Factor VIII and hemophilia A 151
Factor V 177
Thrombin 193
Protein Z and protein Z-dependent protease inhibitor 215
Factor XI 221
Antithrombin III and heparin cofactor II 235
Protein C, protein S, and thrombomodulin 249
Heparin and vascular proteoglycans 271
Fibrinogen structure and physiology 285
Factor XIII and fibrin stabilization 317
Plasminogen - plasmin system 335
Plasminogen activator inhibitor-1 365
Thrombin-activatable fibrinolysis inhibitor aka procarboxypeptidase U
381
[alpha]-Macroglobulins and kunins 395
Human endothelial cell plasmin-generating system 409
Physiologic regulation of fibrinolysis 419
Overview of platelet structure and function 437
Platelet production : cellular and molecular regulation 443
Platelets : structure related to function 463
Thrombopoietin 483
Platelet glycoprotein polymorphisms and relationship to function,
immunogenicity, and disease 493
Molecular mechanisms of drug-induced thrombocytopenia 507
Integrin [alpha][subscript IIb][beta][subscript 3] and platelet
aggregation 517
The platelet glycoprotein Ib/IX/V complex and platelet adhesion 531
Platelet adenosine 5'-diphosphate receptors 547
Protease-activated receptors in hemostasis, thrombosis, and vascular
biology 555
Platelet - collagen receptors 567
Platelet prostanoid receptors 575
Platelet eicosanoids 583
Platelet and megakaryocyte lipids 591
Role of platelets in blood coagulation 605
Platelet signal transduction 617
Overview of vascular biology, embryogenesis, development, and
disorders 631
Development of the vascular system 633
The vascular biology of nitric oxide and nitric oxide synthases 653
Vascular adaptations to altered blood flow 667
Angiogenesis, lymphangiogenesis, and vascular morphogenesis 679
Monocyte-platelet-endothelial interactions 691
Structure and function of von willebrand factor 707
Platelet-vessel wall interactions in flowing blood 723
Rheology of thrombosis 737
Biomaterial-associated thrombosis 751
The vascular response to injury 761
Vessel wall lipids 769
Thrombophilia genetics 779
Inflammation and atherothrombosis 795
Histopathology of atherosclerosis 813
Laboratory markers of platelet activation 825
Laboratory markers of coagulation and fibrinolysis 835
Malignancy and hemostasis 851
Overview of inherited hemorrhagic disorders 877
Clinical manifestations and therapy of the hemophilias 887
von Willebrand disease : diagnosis, classification, and treatment 905
Inherited disorders of prothrombin conversion 923
Afibrinogenemias and dysfibrinogenemias 939
Familial multiple coagulation factor deficiencies 953
Hereditary disorders of platelet secretion and signal transduction
961
Inherited thrombocytopenias 975
Inherited abnormalities of the platelet membrane : Glanzmann
Thrombasthenia, Bernard-Soulier syndrome, and other disorders 987
Primary vascular d