Dubois' Lupus Erythematosus 7/e

Established for forty years as the definitive reference on lupus,
Dubois' Lupus Erythematosus is now in its thoroughly revised, updated
Seventh Edition. More than ninety distinguished contributing authors?
twenty of them new to this edition?provide comprehensive coverage of
every aspect of cutaneous and systemic lupus erythematosus, including
definitions, pathogenesis, autoantibodies, clinical and laboratory
features, management, prognosis, and patient education.

This edition focuses on evidence-based findings, treatment
consensuses, and practical clinical information. New chapters cover
cytokines and interferons, pathogenesis of atherosclerosis, immune
tolerance, clinical indices in assessment of lupus, mixed connective
tissue disease, reproductive issues, fibromyalgia, gender-related
issues, and biomarkers.


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HISTORY AND DEFINITIONS: Historical Background of Discoid & Systemic
Lupus Erythematosus / Definition & Classification of Systemic Lupus
Erythematosus / Environmental Aspects of Lupus / Epidemiology of
Systemic Lupus Erythematosus

PATHOGENESIS: Pathogenesis of Systemic Lupus Erythematosus / Genetics
of Human Lupus / Genetics of Murine Systemic Lupus Erythematosus /
Apoptosis / Interaction of T Cells with Cells of the Innate Immune
System & B Cells in the Pathogenesis of SLE / Cytokines & Interferons
in Lupus / B Cells in Systemic Lupus Erythematosus / Abnormalities in
Immune Complex Clearance & Fcγ Receptor Function / Complement &
Systemic Lupus Erythematosus / Mechanisms of Acute Inflammation &
Vascular Injury in Systemic Lupus Erythematosus / Idiotypes &
Idiotype Networks / The Importance of Sex Hormones in Systemic Lupus
Erythematosus / Neuroendocrine Immune Interactions: Principles &
Relevance to Systemic Lupus Erythematosus / Animal Models of Systemic
Lupus Erythematosus / Pathogenesis of Atherosclerosis in Lupus /
Autoantigens & Defects in Immune Tolerance in Lupus

AUTOANTIBODIES: Structure & Derivation of Antibodies &
Autoantibodies / Antinuclear Antibodies: An Overview / Antibodies to
DNA / Antibodies to Histones & Nucleosome-Related Antigens /
Antibodies to Ro/SSA & La/SSB / Antibodies to Spliceosomal
Components / The Lupus Anticoagulant & Antiphospholipid Antibodies /
Clinical Application of Serologic Abnormalities in Systemic Lupus
Erythematosus

THE SKIN IN LUPUS: Pathomechanisms of Cutaneous Lupus Erythematosus /
Lupus-Specific Skin Disease (Cutaneous LE) / Lupus-Nonspecific Skin
Disease

CLINICAL ASPECTS OF LUPUS: Clinical Presentation of Systemic Lupus
Erythematosus / The Musculoskeletal System / Cardiovascular
Manifestations of Lupus / Pulmonary Manifestations of Systemic Lupus
Erythematosus / Clinical Aspects of Vasculitis & Selected
Cutaneovascular Manifestations of Systemic Lupus Erythematosus / The
Nervous System / Psychopathology of Lupus & Neuroimaging / Head &
Neck Findings in Systemic Lupus Erythematosus: Manifestations
Involving the Eye, Ear & Larynx / Ocular, Aural & Oral
Manifestations / Hematologic & Lymphoid Abnormalities in Systemic
Lupus Erythematosus / Gastrointestinal & Hepatic Manifestations /
Systemic Lupus Erythematosus in Childhood & Adolescence / Drug-
Induced Lupus / Infections in Systemic Lupus Erythematosus / Serum &
Plasma Protein Abnormalities & Other Clinical Laboratory
Determinations in Systemic Lupus Erythematosus / Clinical Indices in
the Assessment of Lupus / Clinical Application of Serologic
Abnormalities in Systemic Lupus Erythematosus / Differential
Diagnosis & Disease Associations / Mixed Connective Tissue Disease &
Overlap Syndromes / The Mother in Systemic Lupus Erythematosus / The
Fetus in Systemic Lupus Erythematosus / Neonatal Lupus / Reproductive
Issues in Women with Autoimmune Disease / Lupus Nephritis: Pathology
& Pathogenesis / Clini