Abeta Peptide and Alzheimer's Disease

Recent advances in genetics and brain biochemistry point to the Abeta
peptide as the major culprit in causing neurodegeneration in
Alzheimer’s Disease (AD). Abeta Peptide and Alzheimer’s Disease is
specifically targeted at summarizing current knowledge of the Abeta
peptide and its role in AD.

Written by leaders in the industrial and academic world specializing
in this rapidly moving area, the book covers fundamental biochemical
studies on this peptide, the genetic impact on Abeta expression and
processing, and various AD therapeutic strategies that target Abeta.
Although specifically focusing on the Abeta peptide and AD, there is
also some discussion on the similarity and differences of this
peptide and AD with other amyloidogenic diseases, such as prion
disease, Parkinsons and Huntingtons. This book will primarily be of
interest to AD researchers and clinicians but also to researchers of
other amyloid diseases.

A Brief Introduction to the History of the ß-Amyloid Protein (Aß) of
Alzheimer’s Disease.- The Aßcentric Pathway of Alzheimer’s
Disease.- The Function of the Amyloid Precursor Protein Family.- The
involvement of Aß in the neuroinflammatory response.- Amyloid ß-
Peptide(1-42), Oxidative Stress, and Alzheimer’s Disease.- Amyloid
Toxicity, Synaptic Dysfunction and the Biochemistry of
Neurodegeneration in Alzheimer’s Disease.- Aß Variants and Their
Impact on Amyloid Formation and Alzheimer’s Disease Progression.-
Copper Coordination by ß-Amyloid and the Neuropathology of
Alzheimer’s Disease.- Cholesterol and Alzheimer’s Disease.- Amyloid
ß peptide and central cholinergic neurons: involvement in normal
brain function and Alzheimer’s disease pathology.- Physiological and
Neurotoxic Properties of Aß Peptides.- Impact of ß-Amyloid on the
Tau Pathology in Tau Transgenic Mouse and Tissue Culture Models.-
Glial Cells and Aß Peptides in Alzheimer’s Disease Pathogenesis.-
The Role of Presenilins in Abeta-Induced Cell Death in Alzheimer’s
Disease.- Immunotherapeutic approaches to Alzheimer’s disease.-
Mouse Models of Alzheimer’s Disease.