Carotid Disease:The Role of Imaging in Diagnosis and Management

Stroke is a major cause of morbidity and mortality, with carotid
disease representing an important contributory risk factor. This book
is about the pathogenesis and management of carotid disease with
specific focus on the role imaging has to play in the early
recognition of symptomatic and asymptomatic disease as well as the
treatment of the developed condition. Technological advances in
imaging modalities now allow detailed analysis of the disease
progression, the prediction of critical events leading to a stroke,
as well as the identification of the most effective surgical or other
interventional treatments. This book should be read by neurologists,
cardiologists, vascular surgeons, neurosurgeons and radiologists
involved in the care of patients with carotid disease, and also by
researchers involved in the development of new therapeutic techniques
and drugs.

Dedication; Abbreviations; Introduction Henry J. M. Barnett;

1. Pathology of carotid artery atherosclerotic disease Renu Virmani,
Allen Burke, Elena Ladich and Frank Kolodgie;

2. Epidemiology of carotid artery atherosclerosis Christopher
O'Donnell;

3. Genetics of carotid atherosclerosis Stephen Rich and Donna Arnett;

4. Haematological processes in emboli formation Alison Goodall and
Greg McMahon;

5. Medical treatment for carotid stenosis Matthew Giles and Peter
Rothwell;

6. Surgical management of symptomatic carotid disease: carotid
endarterectomy and extracranial-intracranial bypass Jonathan Brisman
and Marc Mayberg;

7. Surgery for asymptomatic carotid stenosis Stella Vig and Alison
Halliday;

8. Interventional management of carotid disease Andrew Clifton;

9. Conventional carotid Doppler ultrasound Gregory Moneta;

10. Conventional digital subtraction angiography for carotid disease
Jean Marie U-King-Im and Jonathan Gillard;

11. Magnetic resonance angiography of the carotid artery Martin
Graves, Jean Marie U-King-Im and Jonathan Gillard;

12. Computed tomographic angiography of carotid artery stenosis Paul
Nederkoorn, Charles Majoie and J. Stam;

13. Cost-effectiveness analysis for carotid imaging Jean Marie U-King-
Im, William Hollingworth and Jonathan Gillard;

14. Morphological plaque imaging Chun Yuan and Tom Hatsukami;

15. CT of the plaque Thomas de Weert, Mohamed Ouhlous, Marc van
Sambeek and Aad van der Lugt;

16. Assessment of carotid disease with ultrasound Stephen Meairs;

17. Intravascular ultrasound Gaston Rodriguez-Granillo and Patrick
Serruys;

18. Image post-processing William Kerwin, Dongxiang Xu and Fei Liu;

19. Nuclear imaging for the assessment of patients with carotid
artery atherosclerosis John Davies and Peter Weissberg;

20. USPIO - enhanced MR imaging of carotid atheroma Simon Howarth,
Tjun Tang, Martin Graves, Rikin Trivedi, J. Harle and Jonathan
Gillard;

21. Gadolinium enhanced plaque imaging William Kerwin;

22. Carotid magnetic resonance direct thrombus imaging Alan Moody;

23. The proximal carotid arteries - image-based computational
modelling X. Xu and Nick Wood;

24. Mechanical image analysis using finite element method Tjun Tang,
Chun Yang and Chun Yuan;

25. Transcranial Doppler monitoring Michael Gaunt;

26. MR and CT perfusion Jeroen van der Grond and Matthias van Osch;

27. Near infrared spectroscopy in carotid endarterectomy Pippa Al-
Rawi and Peter Kirkpatrick;

28. Single photon emission computed tomography (SPECT) Kuniaki
Ogasawara;

29. Monitoring carotid interventions with Xenon CT H. Yonas and A.
Carlson;

30. Vascular imaging and the clinical development of new
pharmaceuticals James Revkin and David Lester;

31. Monitoring pharmaceutical interventions with conventional
ultrasound (IMT) John Crouse;

32. Monitoring pharmaceutical interventions with IVUS Stephen
Nicholls, Steven Nissen and Murat Tuzcu;

33. Monitoring of pharmaceutical interventio