Problem-Based Immunology

Features

• Covers each major area of the field – immunization, hypersensitivity,
autoimmunity, immunodeficiency disorders, tumor immunology, and
transplantation. • Provides a concise overview of the basic concepts in each
area, followed by 6-10 succinct and well-organized case studies that illustrate
the associated clinical applications. • Begins each case study with an initial
case presentation, complete with full-color clinical photographs, allowing you
to put your diagnostic reasoning skills to the test – followed by a list of
the key clinical features involved in the case • a one-paragraph discussion of
each differential diagnostic possibility • and a summary of the correct
diagnosis and treatment approach




Contents
IMMUNIZATION
Background
• Rationale for immunization • General principles of immunization • Broad
classes of vaccines • Role of adjuvants • Vaccine efficacy and safety •
Vaccine strategies in development • Novel vaccine applications
Cases
1. Deliberate natural immunization (Leishmania) 2. Immunization in the
bioterrorist era; small pox (or anthrax) 3. Immunization in the elderly
(influenza) 4. Passive immunization: tetanus toxoid 5. Novel approaches for HIV
vaccines 6. Polio vaccines- Salk versus Sabin 7. Cancer vaccine
HYPERSENSITIVITY
Background
• General principles • Gell and Coombs classifications • Sensitization and
effector phases of Types I-IV hypersensitivity reactions
Cases
8. Anaphylaxis 9. Asthma 10. Transfusion reaction 11. Hemolytic disease of the
newborn 12. Serum sickness 13. Farmer’s lung 14. Tuberculosis 15. Poison Ivy
dermatitis
AUTOIMMUNITY
Background
• General principles of tolerance induction • Current evidence/hypothesis for
loss of tolerance • Evidence supporting a role for genetics in autoimmune
disorders • Immunopathology associated with autoreactive antibodies •
Immunopathology associated with T cell mediated damage
Cases
16. Rheumatoid arthritis 17. Systemic lupus erythematosus 18. Graves’ disease
19. Wegener’s granulomatosis 20. Insulin dependent diabetes mellitus 21.
Myasthenia gravis 22. Multiple sclerosis 23. Hashimoto’s thyroiditis
IMMUNODEFICIENCY DISORDERS
Background
• General principles of primary and secondary immunodeficiency disorders •
Dysfunctions that lead to primary immunodeficiency disorders affecting (a) T
cells and B cells combined, (b) T cells, (c) B cells, (d) Complement, (e)
phagocytes • Conditions that lead to secondary immunodeficiencies
Cases
24. Severe combined immunodeficiency disorder 25. DiGeorge’s syndrome 26.
Chronic mucocutaneous candidiasis 27. Bruton’s agammaglobuliniemia
(hypogammaglobulinemia) 28. Selective IgA deficiency 29. Hyper IgM syndrome 30.
Chromic granulomatous disease 31. Hereditary neurotic angioedema 32. C3
complement deficiency or (C8 complement deficiency) 33. Leukocyte adhesion
defect 34. Acquired immunodeficiency disorder 35. Alcoholism and secondary
immunodeficiency
TUMOR IMMUNOLOGY
Background
• General principles of tumor immunology • Tumor specific antigens • Tumor
associated antigens • Immunosurveillance mechanisms for eliminating tumors •
Evasion of immunosurveillance • Novel therapies
Cases
36. Choriocarcinoma (HCG ) 37. Colonic carcinoma (CEA) 38. Melanoma 39.
Multiple myeloma 40. Waldenstrom’s macroglobulinemia 41. Hodgkin’s lymphoma
42. Liver (or testicular) tumor (AFP)
TRANSPLANTATION
Background
• General Features • Surgical and ischemia/reperfusion damage • Role of
activated tissue macrophages and activated vascular endothelial cells •
Adaptive immunity in graft rejection • Tissue matching • Non specific
Immunosuppression • Specific Immunosuppression
Cases
43. Int