Atlas of Heart Failure-4판

Contents

Chapter 1
Molecular and Cellular Basis of Contraction and Relaxation
Structure
Contraction and Relaxation
Cellular Regulation

Chapter 2
Physiology of Myocardial Contraction
Mechanics of Cardiac Contraction
Determinants of Contraction in the Intact Heart
Preload
Contractility
Afterload
Myocardial Energetics
Neural Control of Contractility

Chapter 3
The Etiologic Basis of Congestive Heart Failure
Etiology and Epidemiology
Heart Failure Associated with Coronary Disease
Heart Failure Associated with Valvular Lesions
Idiopathic Dilated Cardiomyopathy
Inflammatory Disease of the Myocardium
Secondary Causes of Cardiomyopathy
Infiltractive/Restrictive Cardiomyopathies
Hypertrophic Cardiomyopathy
Right Ventricular Cardiomyopathy

Chapter 4
Molecular and Cellular Events in Myocardial Hypertrophy and Failure
Ventricular Remodeling
Molecular and Cellular Phenotypes
Calcium Handling and Contractile Protein Expression
Cell Death
Cell Replacement
Extracellular Matrix
β-Adrenergic Pathway
Renin-angiotensin System, Endothelin, and Inflammatory Cytokines

Chapter 5
Cardiac Remodeling and Its Prevention
Cardia Growth and Remodeling
Early Remodeling After Myocardial Infarction and Infarct Expansion
Remodeling and Prognosis
Progressive Enlargement After Myocardial Infarction
Modification of Remodeling After Myocardial Infarction

Chapter 6
Neurohumoral, Renal, and Vascular Adjustments in Heart Failure
Mechanisms in Heart Failure
Sympathetic Nervous System
The Renin-angiotensin-aldosterone System
The Arginine-vasopressin System
Natriuretic Peptides
Local Mechanisms
Regional Blood Flow

Chapter 7
Assessment of Heart Failure
Overview
Assessing the Patient
Diagnostic Tests
Designing a Therapeutic Plan

Chapter 8
Prognostic Indicators and Assessment of Therapeutic Responses
Mortality in Patients with Heart Failure
Use of Prognostic Factors
Assessment of Therapeutic Responses

Chapter 9
Unstable Heart Failure
Acute Heart Failure
Decompensated Chronic Heart Failure

Chapter 10
Diuretics and Digitalis
Diuretics
Digoxin

Chapter 11
Inhibition of the Renin-Angiotensin-Aldosterone System
Angiotensin-converting Enzyme Inhibitors
Aldosterone Receptor Blockade
Angiotensin Receptor Blockers

Chapter 12
β-blockers
Role of Sympathetic Activation
Mechanistic Studies
Randomized Controller Trials
Race and b-Blockers
Differential Effects of β-Blockers
Strategies to Increase β-Blockers Use

Chapter 13
New Approaches to the Treatment of Heart Failure
Neurohormonal Antagonists
Inotropic Agents
Cardiac Resynchronization Therapy
Novel Biologic Therapies for Myocardial Recovery
Treatment of Comorbidities: Anemia, Sleep Apnea, and Pulmonary
Hypertension

Chapter 14
Cardiac Transplantation
Posttransplantaion Survival
Candidate Selection
Donor Selection Criteria
Surgical Techniques
Allograft Rejection
Quality of Life After Transplantion
Accelerated Transplantaion, Atherosclerosis, and Retransplantation

Chapter 15
Diastolic Dysfunction: Pathophysiolgy, Clinical Features, and
Treatment
Normal Diastolic Function
Pathophysiology of LV Diastolic Dysfunction
Diastolic Dysfunction with Ischemia, Hypertrophy, and Other Causes
Aging and Diastolic Dysfunction
Clinical Features, Prognosis, and Treatment

Index

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