Atlas of Atherosclerosis(Risk Factors and Treatment)-4판

Contents

Chapter 1
The Endothelium in Atherothrombosis

Endothelial Regulation of Vasomotor Tone
Endothelial Dysfunction and Inflammation
Endothelial Dysfunction and Thrombosis
Potential Therapies to Improve Endothelial Function

Chapter 2
The macrophage and the Atherosclerotic Process
Lesion Formation
Macrophage Infiltration

Chapter 3
Structure of the Plasma Lipoproteins

Definition and Classification
Basic Structure
Nature of the Bond Formed Between Apolipoproteins and Lipids
High-density Lipoprotein and Atherosclerosis Therapy
Structure of Individual Lipoprotein Classes and Subclasses

Chapter 4
Triglyceride-Rich Lipoproteins

Plasma Triglycerides and Risk of Cardiovascular Disease
Defining Hypertriglyceridemias
Etiology of the Hypertriglyceridemias
Synthesis and Metabolism of Chylomicrons and Very Low-density
Lipoproteins
Specific Defects in Metabolism
Inherited Syndromes with Hypertriglyceridemia
Clinical Trials of Triglyceride-reducing Drugs
Gene Regulation of Apo C-Ⅲ
Role of Apo E in Triglyceride Metabolism
Novel Markers for Coronary Artery Disease and Triglycerides
Metabolism of Triglyceride-rich Lipoproteins, Immune Response, and
Atherosclerosis

Chapter 5
Low-Density Lipproteins in Atherogenesis

Structure of Low-density Lipoproteins
Formation and Clearance of Low-density Lipprotein
Atherogenic Lipproteins
Lipid Peroxidation and Oxidized Low-density Lipoprotein Scavenger
Receptors
Oxidation, Antioxidants, and Atherosclerosis

Chapter 6
High-Density Lipprotein Metabolism

HDL and Premature Cardiovascular Disease
HDL Structure and Metabolism
ABCA1 Transporter
Familial Hyperalphalipoproteinemia
Familial Hypoalphalipoproteinemia

Chapter 7
Dietary Effects on Cardiovascular Risk Factors

Cardiovascular Disease Risk, Diet, and Lifestyle
Dietary Fat and Body Weight
Dietary Patterns
Omega-3 Fatty Acids
Hydrogenated Fat
Dietary Cholesterol
Fiver
Alcohol
Folate and Homocysteine
Plant Sterols
Soy Protein and Soy-derived Isoflavones

Chapter 8
Strategies for Treating Abnormal Lipid Profiles with Drugs

Lipoprotein Metabolism
Statins
Gastrointestinally Active Drugs
Niacin or Nicotinic Acid
Fibrates or Fibric Acid Drugs
Fish Oils or Omega-3 Fatty Acids
Combination Therapy
Conclusions

Chapter 9
The Newer Coronary Risk Factors

Hematologic Factors
Vitamins and Homocysteine
Glucose Metabolism, Insulin, and Insulin Resistance
Imaging

Chapter 10
The Metabolic Syndrome

Major Clinical Outcomes
Metabolic Components (Metabolic Risk Factors)
Pathogenesis (Underlying Risk Factors)
Clinical Criteria for Diagnosis
Risk for Clinical Outcomes
Therapeutic Interventions

Chapter 11
Diabetes Mellitus and Vascular Disease Risk

Incidence of Atherosclerosis in Diabetic Patients
Outcome of Diabetic Patients with Atherosclerosis
Why does Diabetes Increase Atherosclerosis?
Lipoprotein Metabolism and Diabetes Mellitus
Overall Approach

Chapter 12
Gender Differences in Coronary Risk Factors and Risk Interventions

Diabetes Mellitus
Cigarette Smoking
Cholesterol, Lipoproteins, and Triglycerides
Hypertension
Obesity and Body Fat Distribution
Exercise and Physical Fitness
Estrogen Status and Gonadal Hormone Therapy
Miscellaneous

Chapter 13
Cost-Effectiveness of Risk Factors

Overview
Cholesterol Reduction
Hypertension Treatment
Smoking Cessation
Diabetes Treatment