Chronic Obstructive Pulmonary Disease : A Practical Guide to Management

Contents

Section 1: Physiology

1 Structure - Function Realtionships. The Pathology of Airflow
Obstructions

2 The Physiology of Breathlessness

3 The Physiology of Muscle

4 The Physiology of Exercise

5 Clinical Assessment of Control Breathing

6 The Physiology of the Vasculature


7 Sleep in Patients with COPD

8 The Physiology of Cough

9 The Physiology of Gas Exchange


Section 2: COPD and Allied Conditions


10 The Natural History of COPD

11 Cystic Fibrosis

12 Bronchiectasis and COPD

13 Obliterative Bronchiolitis

14 Asthma

15 COPD: Clinical Presentation and Evaluation

16 Monitoring and Outcomes


Section 3: Host Defences and Inflammation


17 Mucociliary Clearance

18 Mucosal Immunity, Systemic Immunity and its Relationship to
Mucosal Immunity

19 COPD and Pulmonary Surfactant

20 The Macrophage and its Role in the Pathogenesis of COPD

21 Eosinophils and COPD

22 Airways Epithelial Defence, Repair and Regeneration

23 Neutrophil

24 Lymphocytes

25 Cytokines

26 Echosinoides

27 COPD and the Vascular Endothelium

28 Mesenchymal Cells


Section 4: Pathogenesis


29 Lung Development

30 Animal Models

31 Proteinases and COPD

32 Oxidants

33 Cigarette Smoke

34 Pollution

35 Viruses in COPD

36 Bacteria

37 Genetic Factors

38 Alpha 1-Antitrypsin Deficiency

39 Body Weight and Ststemic Effects

40 Lung Connective Tissue


Section 5: Clinical Considerations and Complications


41 Aerosols and Delivery Systems

42 Gastroesophageal Reflux Disease (GERD)

43 Upper Airway Diseases

44 Acute Pulmonary Embolism

45 Cancer

46 Infection Management and Airflow Obstruction

47 Mechanical Ventilation for Exacerbation of COPD

48 Comorbidity


Section 6: Current and Future Treatment


49 Primary Care

50 Pulmonary Rehabilitation

51 Social Support

52 Long Term Invasive Mechanical Ventilation

53 Smoking Cessation

54 Oxygen Therapy in COPD

55 Surgery (LVRS)

56 Anti-cholinergics

57 Beta2-agonists

58 Corticosteroids

59 Phosphodiesterase 4 inhibitors in the Treatment of COPD

60 Antibiotic Therapy in Patients with COPD

61 Antioxidants

62 Mucolytics for COPD

63 End-of-life and palliative care of patients with COPD

64 Economic burden of COPD

65 Pharmacoepidemiology of COPD

66 Behavioural Aspects of COPD

67 Guidelines



Section 7: Pharmacotherapy: Developing Therapies


68 Protease inhibitors

69 Retinoids

70 Chemokines in COPD


Index