Somatotrophic Axis in Brain Function 1e

Description

The somatotropic axis is one of the major hormonal systems regulating
postnatal growth in mammals. It interacts with the central nervous
system on several levels. Growth hormone (GH) and insulin-like growth
factor-I (IGF-I) receptors are expressed in many brain areas
including the hippocampus, pituitary and hypothalamus. GH and IGF-I
are important factors in the development and differentiation of the
CNS and have protective properties in dementia, as well as in
traumatic and ischaemic injury of the CNS. Also GH has an important
impact on mood and well-being with GH secretory capacity being
reduced in depression. This volume will include chapters (1) on basic
knowledge on GH/IGF-1, (2) on localization of GH/IGF-1 and their
receptors in the CNS, including blood brain barrier transport of both
hormones, (3) on actions of the two hormones on CNS function (basic
science), (4) on clinical aspects of GH/IGF-1 in relation to various
CNS functions and disorders, and finally (5) on some future
perspectives in this area of science.



Audience
Basic scientists and clinical researchers in neurology,
endocrinology, and neuroscience