Apoptosis and Its Relevance to Autoimmunity

Discusses the major areas of apoptosis research

Over the last 15 years, apoptosis has become a dominant focus of medical
research in the field of immunology. This publication discusses the three major
areas of apoptosis research: extrinsic death receptor pathways, intrinsic cell
death pathways and the mechanisms responsible for apoptotic cell clearance.
Each section delineates the proteins and signal transduction pathways and
describes genetic alterations that lead to autoimmune diseases. Although most
cell death abnormalities have been associated with systemic autoimmune
disorders such as lupus erythematosus and lymphoproliferative syndromes, it is
evident that regulation of cell death is also pertinent to disease expression
in many organ-specific diseases such as rheumatoid arthritis and
glomerulonephritis.
This volume highlights the recent advances in the basic mechanisms of apoptosis
and the application of that knowledge to understanding the impact of defective
apoptosis or defective clearance of apoptotic cells on the immune function and
the expression of disease. It is of special interest to cell biologists,
immunologists and clinicians.


Preliminary Pages
I Contents / Preface
Elkon K (ed): Apoptosis and Its Relevance to Autoimmunity. Curr Dir Autoimmun.
Basel, Karger, 2006, vol 9, pp I-VIII
Article (PDF 46 KB)
Free Access
Extrinsic Death Receptor Pathways
1 Death Receptor Signaling and Its Function in the Immune System
Fas, S. ; Fritzsching, B. ; Suri-Payer, E. ; Krammer, P.
Elkon K (ed): Apoptosis and Its Relevance to Autoimmunity. Curr Dir Autoimmun.
Basel, Karger, 2006, vol 9, pp 1-17
Article (PDF 146 KB) Free Preview Free Abstract

18 Inherited and Acquired Death Receptor Defects in Human Autoimmune
Lymphoproliferative Syndrome
Rieux-Laucat, F.
Elkon K (ed): Apoptosis and Its Relevance to Autoimmunity. Curr Dir Autoimmun.
Basel, Karger, 2006, vol 9, pp 18-36
Article (PDF 555 KB) Free Preview Free Abstract

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37 Tumor Necrosis Factor Ligand-Receptor Superfamily and Arthritis
Hsu, H. ; Wu, Y. ; Mountz, J.
Elkon K (ed): Apoptosis and Its Relevance to Autoimmunity. Curr Dir Autoimmun.
Basel, Karger, 2006, vol 9, pp 37-54
Article (PDF 1100 KB) Free Preview Free Abstract
Intrinsic Death Pathways
55 Mitochondria, Apoptosis and Autoimmunity
Pinkoski, M. ; Waterhouse, N. ; Green, D.
Elkon K (ed): Apoptosis and Its Relevance to Autoimmunity. Curr Dir Autoimmun.
Basel, Karger, 2006, vol 9, pp 55-73
Article (PDF 307 KB) Free Preview Free Abstract

74 Role of Bim and other Bcl-2 Family Members in Autoimmune and Degenerative
Diseases
Hughes, P. ; Bouillet, P. ; Strasser, A.
Elkon K (ed): Apoptosis and Its Relevance to Autoimmunity. Curr Dir Autoimmun.
Basel, Karger, 2006, vol 9, pp 74-94
Article (PDF 157 KB) Free Preview Free Abstract

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95 Mitochondria, Cell Death, and B Cell Tolerance
Deming, P. ; Rathmell, J.
Elkon K (ed): Apoptosis and Its Relevance to Autoimmunity. Curr Dir Autoimmun.
Basel, Karger, 2006, vol 9, pp 95-119
Article (PDF 153 KB) Free Preview Free Abstract
Apoptotic Cell Clearance
120 Role of Complement and Other Innate Immune Mechanisms in the Removal of
Apoptotic Cells
Ogden, C. ; Elkon, K.
Elkon K (ed): Apoptosis and Its Relevance to Autoimmunity. Curr Dir Autoimmun.
Basel, Karger, 2006, vol 9, pp 120-142
Article (PDF 237 KB) Free Preview Free Abstract

143 Collectins: Opsonins for Apoptotic Cells and Regulators of Inflammation
Stuart, L. ; Henson, P. ; Vandivier, R.
Elkon K (ed): Apoptosis and Its Relevance to Autoimmunity. Curr Dir Autoimmun.
Basel, Karger, 2006, vo