Cytogenetics of Human Germ Cells

Exploring the basis and mechanisms of chromosome abnormalities in
human gametes

The world experts in the fields of human gamete cytogenetics and the
etiology of aneuploidy discuss the latest research in this volume.
The frequency and distribution of abnormalities in human oocytes and
sperm are explored, as are the effects of maternal and paternal ages.
Research on basic mechanisms causing aneuploidy, such as decreased
meiotic recombination, defective meiotic checkpoints, skewed X-
chromosome inactivation, and biological aging are elaborated. With
the advent of in vitro fertilization and intracytoplasmic sperm
injection, there has been an explosion of research on the association
of infertility with chromosome abnormalities in gametes. These are
explored both for individuals with somatic chromosome abnormalities
and for infertile patients who have a normal karyotype but still
produce gametes with an increased frequency of cytogenetic
abnormalities. The most recent research on meiotic abnormalities in
these infertile patients is included. Since humans have such a
devastating load of numerical chromosome abnormalities, environmental
and lifestyle issues are discussed and related to mammalian model
systems.
This up-to-date and comprehensive volume will be a resource for
geneticists, cell biologists, infertility experts, reproductive
scientists, obstetricians, andrologists, and staff of assisted
reproductive clinics.


Special Section
187 Title Page / Table of Contents
Cytogenet Genome Res 2005;111:187-190 (DOI:10.1159/000088629)
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Preface
191 Unraveling the secrets of sex cells
Martin, R. ;
Cytogenet Genome Res 2005;111:191-192 (DOI:10.1159/000088630)
Article (PDF 40 KB)



Frequency and Distribution of Cytogenetic Abnormalities in Human Germ
Cells
193 Frequency and distribution of chromosome abnormalities in human
oocytes
Kuliev, A. ; Cieslak, J. ; Verlinsky, Y.
Cytogenet Genome Res 2005;111:193-198 (DOI:10.1159/000086889)
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199 Frequency and distribution of chromosome abnormalities in human
spermatozoa
Templado, C. ; Bosch, M. ; Benet, J.
Cytogenet Genome Res 2005;111:199-205 (DOI:10.1159/000086890)
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206 Effect of maternal age on the frequency of cytogenetic
abnormalities in human oocytes
Pellestor, F. ; Anahory, T. ; Hamamah, S.
Cytogenet Genome Res 2005;111:206-212 (DOI:10.1159/000086891)
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213 Effect of paternal age on the frequency of cytogenetic
abnormalities in human spermatozoa
Buwe, A. ; Guttenbach, M. ; Schmid, M.
Cytogenet Genome Res 2005;111:213-228 (DOI:10.1159/000086892)
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229 Individual variation in the frequency of sperm aneuploidy in
humans
Rubes, J. ; Vozdova, M. ; Oracova, E. ; Perreault, S.D.
Cytogenet Genome Res 2005;111:229-236 (DOI:10.1159/000086893)
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Research on Basic Mechanisms Causing Aneuploidy
237 Mechanisms of aneuploidy induction in human oogenesis and early
embryogenesis
Delhanty, J.D.A.
Cytogenet Genome Res 2005;111:237-244 (DOI:10.1159/000086894)
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