Structural Proteomics-1판

Structural Proteomics

FROM THE PUBLISHER
"Researchers in structural genomics continue to search for biochemical and
cellular functions of encoded proteins as well as the ways in which proteins
assemble into functional pathways and networks using either experimental or
computational approaches. Based on the experience of leading international
experts, Structural Genomics and High Throughput Structural Biology details
state-of-the-art analytical and computational methods used to reveal the three-
dimensional structure and function of proteins." This book concludes with a
discussion of practical applications of proteomics, particularly
therapeutically driven structural genomics, and presents future directions in
the field. Structural Genomics and High Throughput Structural Biology offers a
comprehensive guide to the technological, and experimental methologies used to
derive structural information encoded proteins.

TABLE OF CONTENTS
Ch. 1 Overview of structural genomics : landscape, premises, and current
direction 1
Ch. 2 Purifying protein for structural biology 19
Ch. 3 Protein crystallization : automation, robotization, and miniaturization
29
Ch. 4 NMR spectroscopy in structural genomics 49
Ch. 5 High throughput protein crystallography 61
Ch. 6 From sequence to function 105
Ch. 7 Comparative modeling and structural proteomics 109
Ch. 8 Ab initio modeling 137
Ch. 9 Determining function from structure 163
Ch. 10 Retrieval and validation of structural information 185
Ch. 11 Problems in computational structural genomics 223
Ch. 12 Applied structural genomics 251