Cardiac Mechano-Electric Feedback and Arrhythmias-1판

Description
Better understand the mechanisms of arrhythmia, cellular modifiers,
and the clinical answers to these disorders! Written by
internationally recognized leaders in the field, this groundbreaking
resource reflects the state of the art in all aspects of mechanical
heart function. Readers will find detailed discussions of mechanisms
of feedback * effects on cellular electrophysiology * experimental
manifestations * normal physiology * pathogenic mechanisms *
therapeutic interventions * and more.




-Table of Contents-


Introduction
* Cardiac mechano-electric interactions and the induction &
termination of arrhythmia
Fundamental Mechanisms of Cardiac Mechano-Electric Feedback
* Cardiac non-selective stretch-activated cation channels:
pathophysiological potential * Mechanical modulation of cardiac
potassium channels * Cell-volume activated ion channels in cardiac
cells * Contribution of cytoskeleton and lipid bi-layer to cellular
mechano-reception * The response of cardiac muscle to stretch: role
of calcium * Stretch-effects on second messengers and early gene
expression
Cellular Effects of Mechano-Electric Feedback
* Differential effects of stretch on cardiac cells in diastole and
systole * Differential effects of stretch and compression of cardiac
cells * Mechanical modulation of cardiac non-myocyte structure and
function * Mechanical effects on auto- & paracrine signalling in
cardiac myocytes and non-myocytes * Stretch effects on connexin
expression in cardiac cells
Mechano-Electric Feedback in Cardiac Tissue and Whole Heart
* Mechanical modulation of sino-atrial pacemaking rate * Stretch
effects on atrial conduction and refractoriness * Stretch effects on
ventricular conduction and refractoriness * Neuro-humoral modulation
of cardiac mechano-electric interactions * Mechanically-induced
repolarization dispersion and the mechanical vulnerable period *
Experimental arrhythmogenesis by acute mechanical stimulation
(Commotio cordis) * Specific stretch-channel blockers: a new class of
anti-arrhythmic drugs
Clinical Evidence for Cardiac Mechano-Electric Feedback in Man
* Non-neuronal component of respiratory sinus arrhythmia * Induction
of arrhythmias by precordial impact * Arrhythmogenesis during cardiac
catheterisation * Role of transmural gradients in mechano-electric
interactions * Hemodynamic unloading and termination of arrhythmias *
Bypass-induced ventricular load changes and action potential
configuration * Termination of ventricular arrhythmia by acute
mechanical interventions
Clinical Relevance of Cardiac Mechano-Electric Feedback
* Cardiac mechanics and the ECG U-wave * Arrhythmias in ischaemic
heart disease in linkage with regional wall motion abnormalities *
Arrhythmogenic potential of dysynergy of ventricular mechanics in
patients with heart failure and wide QRS complex * Bi-ventricular
pacing as a new treatment modality to restore ventricular
synchronization * Atrial fibrillation in dilated cardiomyopathy * The
angiotensin-renin pathway in left ventricular hypertrophy and SCD *
Volume and pressure overload and ventricular arrhythmogenesis *
Mortality from heart failure: haemodynamic versus electrical causes *
Passive ventricular constraint: new treatment concept for dilated
cardiomyopathy * Mechanical modulation of defibrillation efficacy by
preload changes * Mechanical advances in cardiopulmonary resuscitation
Clinical Trials Evaluating Survival Benefits by Ventricular Unloading
or Resynchronization
* Effects of bi-ventricular pacing on cardiac mortality and
arrhythmias ?the Companion trial * InSync Trial * Counter-pulsation
and cardiac assist devices. * New intra-ventricular chamber reduction
devices (Percutaneous catheter mediated endocardial ventriculoplasty
for patients with heart failure). * Ventricular restraint study and
reverse re-modeling in patients. * Evolving concepts in mea