Severe Acute Respiratory Syndrome:A Clinical Guide

Prompting the first WHO global health alert for over a decade, Severe Acute
Respiratory Syndrome (SARS) was first recognised in South-East Asia in February
2003. With the causative agent now identified as a new strain of coronavirus,
the medical world has gained important knowledge on the aetiology, clinical
presentation, diagnosis, pathogenesis, epidemiology, disease treatment and
infection control with amazing speed. Despite this, major gaps remain in our
understanding - the race is on to develop new cures and effective vaccines, and
the long-term impact on health, society and economics are starting to
unravel. "Severe Acute Respiratory Syndrome: A Clinical Guide" meets the urgent
need for a comprehensive, authoritative reference guide for everyone in the
medical and scientific community engaged in the fight against SARS. It is a
definitive book on SARS, clearly and accurately documenting the extraordinary
medical and scientific events around this new epidemic. International experts
in the field, several from WHO and CDC contribute to this book. It will help
reader to understand and prevent future outbreaks with a repeat of the same
consequences.






FOREWORD: Joshua Lederberg (USA)
SECTION 1 : AN OVERVIEW 1.
1 SARS: An historical overview - KY Yuen and ZN Zhong Nan-Shan (HK and China)
1. 2 SARS: A global perspective - David Heymann (Switzerland) and Klaus Stohr
(WHO)

SECTION 2: THE DISEASE
2. 1 Clinical presentation of the acute disease - J Sung (HK), KY Yuen (HK)
2. 2 SARS in Children - CW Leung (HK)
2. 3 Pulmonary and other sequelae and rehabilitation - K Tsang (HK), David Hui
(HK), KS Chan (HK)
2. 4 Radiology - C. Ooi (HK)
2. 5 Pathology and Pathogenesis: J Nicholls (HK) and T Kuiken (Holland)

SECTION 3: AETIOLOGY
3. 1 The viral aetiology: Peris (HK) and Osterhaus (Holland)
3. 2 SARS coronaviruses genome - Rota (CDC) and Ed Lui (Singapore)
3. 3 Laboratory Diagonis - Drosten (Hamburg) and Poon (HK) and Erdman (CDC)
3. 4 SARS coronaviruses: An Animal Reservoir - Guan (HK) and Hume Field
(Australia) (and Beijing Geonomics Institute?)
3. 5 Comparative biology of coronavirus infections: Lessons for SARS - Saif
(Ohio, USA)

SECTION 4: EPIDEMIOLOGY
4. 1 The seasonality of respiratory viruses: Implications for SARS? - W Lim
(HK) and Jan de Jong (Holland)
4. 2 Epidemiology and Transmission - Klaus Stohr (WHO)
4. 3 Epidemiological modeling - Anderson and Gabriel Leung (UK and HK)

SECTION 5: INTEVENTION STRATEGIES
5. 1 Public Health Response: A View From three cities - Arelene King, CC Tan
(Singapore), T Tsang (HK), Maraget Chan (HK)
5. 2 Public Health Response: A View From Low Endemic Regions - S Van der Werf
5. 3 International Measures -
5. 4 The WHO Response - Guenael Rodier (Switzerland)
5. 5 Reducing Hospital Transmission - WH Seto (HK)
5. 6 Antivirals
5. 7 Vaccines - Kanta Subbarao

SECTION 6: SOCIO-ECONOMIC IMPACT
6. 1 Crisis Management in the Health Care Setting - EK Yeoh (HK)
6. 2 Counting the Cost: The Economic and Social Cost of SARS - RYC Wong (HK),
Alan Sui (HK)
6. 3 Communication, Media and Public Education -
SECTION 7: LESSONS FOR THE FUTURE
7. 1 Lessons for the Future: Response Preparedness for the Return of SARS - L
Anderson (CDC, USA)
7. 2 Lessons for the Future: Other Emerging Infections - Ab Osterhaus
(Netherlands)
7. 3 Lessons for the Future: Pandemic influenza - R Webster (USA) INDEX