Fatty Liver Disease

Long Description
Fatty liver disease, especially non-alcoholic steatohepatitis (NASH), is
emerging as the most common form of liver disease - affecting at least 5% of
the population of western countries with increasing incidence in developing
economies in other continents (particularly Asia, Australia, South America and
South Africa). NASH is the form of fatty liver disorder which can result in
cirrhosis, particularly in those with diabetes or who are overweight, yet it is
still not widely recognised as the most common form of liver disease. This book
explains what NASH is, why it happens, who gets it, how it can result in
cirrhosis, when to think about it, how to select practical management between
those with a minor abnormality from those who may have cirrhosis, and how to
prevent and treat this ubiquitous condition. Fatty Liver Diseases: NASH and
Related Disorders is an unusual book: it combines a practical approach for
students and physicians concerned with the problem with a clear overview on the
causative mechanisms.
It should appeal to doctors and other health care workers who encounter this
problem, as well as to pathologists and investigators interested in the field
of liver disease. There is a dearth of assembled information about NASH: such
information is sought by physicians of various backgrounds, and detailed
information is required by gastroenterologist, hepatologists, general
physicians, diabetologists, nutritionalists and pathologists. Information on
the diagnosis, management and understanding of this disease is only available
in recent reviews - it is not covered in standard texts and there is no
specific book available on the subject so far. The reader will benefit from the
book by improving their diagnostic acumen for people with abnormal liver tests,
improving knowledge about an important subject that will assist them in
specialist or undergraduate exams, and will improve management of a common
disorder.


Table of Contents
1 Overview : an introduction to NASH and related fatty liver disorders by
Geoffrey C. Farrell and Jacob George and Pauline de la M. Hall and Arthur J.
McCullough 1
2 Pathology of hepatic steatosis, NASH and related conditions by Pauline de la
M. Hall and Richard Kirsch 13
3 The epidemiology and risk factors of NASH by Arthur J. McCullough 23
4 Insulin resistance in NAFLD : potential mechanisms and therapies by Varman
T. Samuel and Gerald I. Shulman 38
5 NASH as part of the metabolic (insulin resistance) syndrome by Giulio
Marchesini and Elisabetta Bugianesi 55
6 NASH is a genetically determined disease by Christopher P. Day and Ann K.
Daly 66
7 The pathogenesis of NASH : human studies by Arun J. Sanyal 76
8 Animal models of steatohepatitis by Geoffrey C. Farrell 91
9 Fatty acid metabolism and lipotoxicity in the pathogenesis of NAFLD/NASH by
Nathan M. Bass and Raphael B. Merriman 109
10 Cytokines and inflammatory recruitment in NASH : experimental and human
studies by Zhiping Li and Anna-Mae Diehl 123
11 Mitochondrial injury and NASH by Bernard Fromenty and Dominique Pessayre
132
12 Cell biology of NASH : fibrosis and cell proliferation by Isabelle A.
Leclercq and Yves Horsmans 143
13 Clinical manifestations and diagnosis of NAFLD by Stephen A. Harrison and
Brent Neuschwander-Tetri 159
14 The clinical outcome of NAFLD including cryptogenic cirrhosis by Stephen H.
Caldwell and Anita Impagliazzo Hylton 168
15 Practical approach to the diagnosis and management of people with fatty
liver diseases by Jacob George and Geoffrey C. Farrell 181
16 Management of NASH : current and future perspectives on treatment by Paul
Angulo and Keith D. Lindor 194
17 NAFLD, NASH and orthotopic liver transplantation by Anne Burke and Michael
R. Lucey 208
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