Brain Tumors : Contemporary Cancer Research

TABLE OF CONTENTS
1 Epidemiology of brain tumors 3
2 Molecular genetics of tumors of the central nervous system 19
3 Molecular pathology of nervous system tumors 33
4 Genetic modeling of glioma formation in mice 55
5 Biology of brain metastasis 91
6 Analysis of neural precursor cells in the context of origin of brain tumors,
their treatment, and repair of treatment-associated damage 107
7 Biology of primitive neuroectodermal tumors 125
8 Molecular and cellular biology of the blood-brain barrier and its
characteristics in brain tumors 157
9 Immune regulation in the brain : lessons from autoimmunity and implications
for brain tumor therapy 175
10 Genetic pathways in the evolution of gliomas 207
11 DNA damage and repair in the therapeutic response of tumors of the central
nervous system 223
12 Role of urokinase-type plasminogen activator receptor in human glioma
invasion 237
13 Regulation of cell cycle and apoptosis in human brain tumors 249
14 Systemic chemotherapy for metastatic tumors of the central nervous system
267
15 Radiation biology and therapy of tumors of the central nervous system 279
16 Advances in the management of cerebral metastases 307
17 Immunotherapy of central nervous system tumors : contemporary cancer
research 323
18 Targeting drugs to tumors of the central nervous system 343
19 Rational design and development of targeted brain tumor therapeutics 359