Inborn Errors of Development

. GENERAL CONCEPTS
1. Introduction, Charles J. Epstein
2. General Principles of Differentiation and Morphogenesis, Scott F. Gilbert
3. Model Organisms in the Study of Development and Disease, Ethan Bier and
William McGinnis
4. Consequences of the Genome Project for Understanding Development, David W.
Mount
II. PATTERNS OF DEVELOPMENT
5. Developmental Origins of the Mammalian Body Plan, Michael M. Shen and Roger
A. Pedersen
6. Neural Crest Formation and Craniofacial Development, Deborah Lang,
Christopher B. Brown, and Jonathan A. Epstein
7. Development of the Nervous System, John L.R. Rubenstein and Luis Puelles
8. Development of the Ear, Donna M. Fekete
9. Development of the Heart and Vasculogenesis, Wolfgang Rottbauer and Mark C.
Fishman
10. Development of Muscle and Somites, Alan Rawls and Jerry M. Rhee
11. Development of Bone and Cartilage, Shunichi Murakami, Haruhiko Akiyama, and
Benoit de Crombrugghe
12. Development of the Limbs, Sahir Nissim and Cliff Tabin
13. Development of the Genitourinary System, Dylan Steer, Kazuhito Fukuoka,
Stanley Mendoza, and Sanjay Nigam
14. Development of Endodermal Derivatives in the Lung, Liver, Pancreas, and
Gut, Ben Z. Stanger and Douglas A. Melton
15. Development of Epidermal Appendages: Teeth and Hair, Atsushi Ohazama and
Paul T. Sharpe
III. DEFINED PATHWAYS
Part A. The Sonic Hedgehog Signaling Pathway
16. An Introduction to Sonic Hedgehog Signaling, M. Michael Cohen, Jr.
17. DHCR7 and the Smith-Lemli-Opitz (RSH) Syndrome and Cyclopamine
Teratogenesis, Mira Irons
18. SHH, ZIC2, SIX3, TGIF, PTCH, GLI2, FAST1, TDGF1, and DHCR7 and
Holoprosencephaly, M. Michael Cohen, Jr.
19. PTCH and the Basal Cell Nevus (Gorlin) Syndrome, Ervin Epstein, Jr.
20. GLI3 and the Pallister-Hall and Greig Cephalopolysyndactyly Syndromes,
Leslie G. Biesecker
21. SALL1 and the Townes-Brocks Syndrome, Jurgen Kohlhase and Wolfgang Engel
Part B. The Wnt (Wingless-Type) Signaling Pathway
22. Wnt Signaling Pathways, Laird C. Sheldahl and Randall T. Moon
23. WISP3 and Progressive Pseudoheumatoid Dysplasia, Wafaa Suwairi and Matthew
L. Warman
Part C. The Transforming Growth Factor (TGF-B) Signaling Pathway
24. An Introduction to TGF-B-Related Signaling, Anna Petryk and Michael B.
O'Connor
25. NOG and Proximal Symphalangisms, Multiple Synotosis, and Fibrodysplasia
Ossifican Progressiva, Matthew L. Warman
26. ZIC3, CFC1, ACVR2B, and EBAF and the Visceral Heterotaxies, Stephanie M.
Ware and John W. Belmont
27. CDMP1 and Chondrodysplasia (Grebe, Hunter-Thompson, and Du Pan Types) and
Brachydactyly, Type C, Michael W. Kilpatrick and Petros Tsipouras
ENG and ALK1 and Hereditary Hemorrhagic Telangiectasia
(Osler-Weber-Rendu Syndrome) and Vascular Morphogenesis Douglas A. Marchuk and
Jonathan N. Berg
28. ENG and ALK1 and Hereditary Hemorrhagic Telangiectasia (Osler-Weber-Rendu
Syndrome) and Vascular Morphogenesis, Douglas A. Marchuk and Jonathan N. Berg
29. RUNX2 and Cleidocranial Dysplasia, Brendan Lee and Guang Zhou
Part D. The Tumor Necrosis Factor Signaling Pathway
30. Signaling by TNF and Related Ligands, Pascal Schneider
31. EDA, EDAR, and EDARADD and the Hypohidrotic Ectodermal Dysplasias and
Ectodysplasin Signaling Pathway, Jonathan Zonana Part E. The Fibroblast Growth
Factor Signaling Pathway
32. Molecular and Cellular Biology of FGF Signaling, David Givol, Veraragavan
P. Eswarakumar, and Peter Lonai
33. FGFR1, FGFR2, and FGFR3 and Achondroplasia, Hypochondroplasia,
Thanatophoric Dysplasia, Autosomal Dominant Hypophosphatemic Rickets and the
Apert, Beare-Stevenson Cutis Gyrata, Crouzon, Crouzonodermoskeletal, Jackson-
Weiss, Muenke, Pfeiffer, and SADDAN Syndromes, M. Michael Cohen, Jr.
34. TWIST and the Saethre-Chotzen Syndrome, Ethylin Wang Jabs Part F. The Glial
Cell-Derived Neurotrophic Factor Signaling Pathway 35. Signaling Pathways of
Glial Cell-Derived Neurotrophic Factor, Louis F. Reichardt
36. RET and Hirsch