Joslin's Diabetes Mellitus

1 The History of Diabetes 1
2 Islets of Langerhans: Morphology and Its Implications 15
3 Insulin Biosynthesis and Chemistry 29
4 Cell Biology of Insulin Secretion 56
5 Insulin Secretion in Vivo 81
6 Hormone-Fuel Interrelationships: Fed State, Starvation, and Diabetes Mellitus
97
7 Alterations in Protein Metabolism in Diabetes Mellitus 116
8 Molecular Aspects of Insulin Action 139
9 Glucagon 163
10 Peptide Growth Factors 177
11 Definition, Diagnosis, and Classification of Diabetes Mellitus and Impaired
Glucose Tolerance 193
12 Epidemiology and Genetics of Diabetes Mellitus 201
13 Pathogenesis of Insulin-Dependent (Type I) Diabetes Mellitus 216
14 Pathogenesis of Non-Insulin-Dependent (Type II) Diabetes Mellitus 240
15 Pathology of the Pancreas in Diabetes Mellitus 265
16 Syndromes of Extreme Insulin Resistance 282
17 Secondary Forms of Diabetes 300
18 Use of Animal Models in the Study of Diabetes 317
19 Obesity 351
20 Treatment of Obesity 363
21 The Pathophysiology and Treatment of Lipid Disorders in Diabetes Mellitus
372
22 General Approach to the Treatment of Diabetes 397
23 Education in the Treatment of Diabetes 404
24 Dietary Management 415
25 Psychosocial Aspects of Diabetes 431
26 Exercise and Diabetes 451
27 Principles of Insulin Therapy 460
28 Iatrogenic Hypoglycemia 489
29 Oral Antidiabetic Agents 508
30 Treatment of the Child with Diabetes 530
31 Treatment of the Elderly with Diabetes 552
32 Whole-Pancreas and Islet-Cell Transplantation 560
33 Alternative Approaches to Insulin Therapy and Recent Advances in Implantable
Glucose Sensors 570
34 Economic and Social Costs of Diabetes 586
35 Epidemiology of Late Complications of Diabetes 605
36 Relationship between Metabolic Control and Long-Term Complications of
Diabetes 620
37 Mechanisms of Diabetic Microvascular Complications 631
38 Pathogenesis of Macrovascular Disease in Diabetes 648
39 Pathogenesis of Diabetic Neuropathy 665
40 Diabetic Nephropathy 691
41 Diabetic Ketoacidosis and the Hyperglycemic, Hyperosmolar Nonketotic State
738
42 Ocular Complications of Diabetes Mellitus 771
43 The Nervous System and Diabetes 794
44 Hypertension 817
45 Heart Disease in Diabetes 836
46 Erectile Dysfunction and Diabetes 852
47 Infection and Diabetes 867
48 Diabetes and Pregnancy 889
49 Skin Manifestations of Diabetes Mellitus 900
50 Joint and Bone Manifestations of Diabetes Mellitus 912
51 Effects of Diabetes Mellitus on the Digestive System 921
52 Surgery and Diabetes 955
53 Foot Lesions in Patients with Diabetes: Cause, Prevention, and Treatment 962
54 Vascular Disease of the Lower Extremities in Diabetes Mellitus: Etiology and
Management 970
55 Hypoglycemia 976
56 Endocrine Tumors of the Pancreas 1000
Index 1023