Neural Mechanisms of Anesthesia

TABLE OF CONTENTS
Preface
Contributors
1 The Development of Concepts of Mechanisms of Anesthesia 3
2 Mechanisms of Consciousness with Emphasis on the Cerebral Cortical Component
13
3 Anesthesia Meets Memory: Tools for Critical Appraisal 21
4 Sleep and Anesthesia 65
5 Possible Relationships of Anesthetic Coma and Pathological Disorders of
Consciousness 75
6 Cerebral Cortex - Anesthetic Action on the Electroencephalogram: Cellular and
Synaptic Mechanisms and Clinical Monitoring 93
7 Cerebral Mechanisms of Analgesia and Anesthesia in Humans Elucidated by In
Vivo Brain Imaging 113
8 Thalamus 125
9 The Hippocampus 149
10 Anesthetic Effects on the Reticular Formation, Brainstem and Central Nervous
System Arousal 169
11 Anesthesia, the Spinal Cord and Motor Responses to Noxious Stimulation 183
12 Spinal Cord-Dorsal Horn 205
13 Spinal Cord: Anesthetic Actions on Motor Neurons 215
14 Simple Genetic Models for Anesthetic Action 231
15 Genetic Dissection of Anesthetic Action 249
16 General Anesthetic Effects on GABA[subscript A] Receptors 265
17 Nicotinic Acetylcholine Receptors and Anesthetics 283
18 Actions of General Anesthetic on Voltage-Gated Ion Channels 299
19 Glutamate Receptors: Physiology and Anesthetic Pharmacology 319
20 General Anesthetic Effects on Glycine Receptors 333
21 Presynaptic Actions of General Anesthetics 345
22 The Meyer-Overton Relationship and Its Exceptions 371
23 Protein Models 395
24 The Opioid Receptors 413
25 Local Anesthetics 427
26 Neuromuscular Blocking Agents and General Anesthesia 441
27 The Future of Anesthetic Mechanisms Research 449
Index 455