Cancer Gene Therapy

1 Cancer gene therapy : historical perspective 1
2 The genetic basis of cancer 9
3 Tumor suppressor gene replacement for cancer 19
4 Antisense technology 35
5 Cancer therapeutic applications of ribozymes and RNAi 51
6 Fusogeneic membrane glycoproteins for cancer gene therapy : a better class of
killer 65
7 Suicide gene therapy 81
8 Molecular chemotherapy approaches 109
9 Genetic immunotherapy approaches 129
10 Immunotherapy of cancer by dendritic cell-targeted gene transfer 143
11 Dendritic cells 173
12 Polynucleotide immunization for cancer therapy 185
13 Development of oncolytic replication-competent herpes simplex virus
vectors : the G207 paradigm 199
14 Development of oncolytic adenoviruses : from the lab bench to the bedside
211
15 Conditionally replicating adenoviruses for cancer treatment 235
16 Reovirus as an oncolytic agent 249
17 Antiangiogenic gene therapy of cancer 261
18 Proapoptotic strategy in cancer gene therapy 273
19 Antimetastasis 287
20 Antimetastatic gene therapy : prostate cancer theory to therapy 299
21 Drug resistance gene transfer as an antitumor strategy 321
22 Chemosensitization 335
23 Radiosensitizaton by gene theraphy 349
24 Nonviral vector systems for cancer gene therapy 367
25 Viral vectors for cancer gene therapy 379
26 Bacterial systems for tumor-specific gene therapy 393
27 Molecular imaging of cancer gene therapy 405
28 Cancer-related gene therapy clinical trials 427
29 Regulatory aspects in the development of gene therapies 441