1 General consideration in the use and application of laboratory tests for the
evaluation of cancer 3
2 New insights and future advances in cancer diagnostics : limitations of
conventional tumor markers 15
3 The changing role of the pathologist in the management of the cancer patient
27
4 Types of circulating tumor markers and their clinical applications 35
5 Identification of risk factors for early neoplasm 53
6 Emerging circulating tumor markers 65
7 Prostate cancer markers : from discovery to the clinic 85
8 Serum tumor marker test profile in testicular germ-cell tumors 129
9 Autoantibodies, autoimmunity, and cancers : markers for identification of
early stages of tumors 169
10 MHC tetramers : a tool for direct ex vivo detection and enumeration of tumor-
specific cytotoxic T lymphocytes 185
11 New applications of flow cytometry in cancer diagnosis and therapy 199
12 Molecular diagnostics in neoplastic hematopathology 233
13 HER2 and topoisomerase II[alpha] in breast carcinoma 261
14 Study of sentinel lymph nodes in the staging of malignant neoplasms 285
15 A marker for early diagnosis of lung cancer : the heterogeneous nuclear
ribonucleoprotein A2/B1 (hnRNP A2/B1) 307
16 Molecular techniques in cancer diagnosis and management 325
17 DNA repair defects in cancer 361
18 Chromosomal and molecular cytogenetic assays for evaluation of human tumors
379
19 Microsatellite alterations as diagnostic and prognostic molecular markers in
patients with cancer 395
20 Recent advances in molecular classification and prognosis of colorectal
cancer 429
21 Genetic counseling for hereditary cancer predisposition testing 453
22 Diagnosis of ataxia-telangiectasia : ATM mutations associated with cancer
473