Cell Cycle Inhibitors in Cancer Therapy : Current Strategies

Preface
Contributors
1 Cdk Inhibitors: Background and Introduction 1
2 p27, A Prognostic Indicator Reflecting ...? 11
3 Cell Cycle Control of Transcription at the G1/S Phase Transition 31
4 Tumor-Suppressor Genes as Diagnostic Tools 49
5 Regulation of Cell Cycle and Apoptosis 83
6 CDK Inhibitors as Targets of Chemoprevention Agents 119
7 Cell Cycle Regulatory Genes as Targets of Retinoids 145
8 Modulators of Cyclin-Dependent Kinases: A Novel Therapeutic Approach for the
Treatment of Neoplastic Diseases 179
9 Cell Cycle Regulators: Interactions and Their Role in Diagnosis, Prognosis,
and Treatment of Cancer 207
10 Cell Cycle Regulators as Targets of Anticancer Therapy 253
11 Mammalian CDk Inhibitors as Targets of Ubiquitinization in Cancer 277
12 Synthetic Oligopeptides as Cancer Cell Cycle Modulators 297
Index 311