Chemotherapy for Gynecologic Neoplasms : Current Therapies and Novel Approaches

TABLE OF CONTENTS
Foreword
1 Antineoplastic agents : classification and mechanisms of action 1
2 Mechanisms of chemosensitivity and resistance 13
3 In vitro testing for drug sensitivity/resistance 47
4 Basic principles of dose intensity and high-dose chemotherapy 57
5 Immunotherapy in gynecologic malignancies 67
6 Gene therapy of ovarian cancer 93
7 Basic concepts of chemotherapy sequence and combinations 119
8 Pharmacoeconomic applications in gynecologic oncology 137
9 Guidelines to writing a clinical protocol 145
10 Evaluation of gynecologic tumor response : when and how? 173
11 Practical guide on how to deliver chemotherapy 187
12 Evaluation of the patient for chemotherapy 201
13 Chemotherapy in pregnancy 207
14 Supportive treatment in gynecologic malignancies 233
15 Hormone replacement therapy in gynecologic cancer patients and survivors 245
16 Infections in patients with gynecological malignancies : prevention and
management 257
17 Pharmacologic pain management in gynecologic oncology 275
18 Blood transfusion during chemotherapy : risks and benefits 297
19 Role of tumor markers in gynecologic oncology 307
20 Role of chemoprotectors during chemotherapy for gynecologic neoplasms 317
21 Chemoprevention in gynecological oncology 325
22 Role of psychological support during chemotherapy 345
23 Quality of life during chemotherapy : recent results and methodological
challenges of conducting quality-of-life studies with gynecological cancer
patients 355
24 Ovarian cancer 367
25 Management of early epithelial ovarian cancer 379
26 Chemotherapy for advanced primary epithelial ovarian cancer : neoadjuvant
and adjuvant 391
27 Persistent and recurrent ovarian cancer 407
28 Intraperitoneal chemotherapy : basic concepts and clinical trials 433
29 Chemotherapy for germ cell tumors 441
30 Chemotherapy for sex cord-stromal tumors 459
31 Ovarian cancer : rationale and strategies beyond first-line treatment 471
32 Fallopian tube cancer 483
33 Chemotherapy of fallopian tube cancer 489
34 Endometrial cancer 497
35 Medical therapy for endometrial hyperplasia and early endometrial cancer in
patients desiring future childbearing 507
36 Uterine carcinomas : chemotherapy for primary and recurrent tumors 519
37 Chemotherapy in uterine mesenchymal tumors 529
38 Cervical cancer 547
39 Neoadjuvant chemotherapy in cervical cancer 555
40 Chemoradiation therapy for cervical cancer 573
41 Chemotherapy for recurrent and advanced cervical cancer 589
42 Vulvar cancer 609
43 Chemotherapy in vulvar cancer 617
44 Vaginal cancer 625
45 Vaginal cancer chemotherapy 631
46 Management of hydatidiform mole 637
47 Trophoblastic disease 647
48 Rare tumor : melanoma - lymphoma - sarcoma 661