Osteoporosis in Clinical Practice : A Practical Guide for Diagnosis and Treatment

Contributors xiii
Abbreviations xix
Introduction: General Outlines of Assessment and Management of
Osteoporosis: Postmenopausal Osteoporosis as an Example xxiii
Part 1 General aspects of bone, osteoporosis and fractures
1 Normal Skeletal Structure and Function 3
2 Physiology of Calcium Homeostasis and Bone Remodeling 9
3 Biomechanics of Bone and Fracture 15
4 Pathophysiology of Fractures 21
5 Epidemiology of Osteoporotic Fractures 29
6 Socioeconomic Impact 39
Part 2 Investigations in Osteoporosis
7 Bone Densitometry, Radiography, and Quantitative Ultrasound
for the Diagnostic Assessment of Osteoporosis 47
8 Biochemical Indices of Bone Turnover 59
9 Dual-energy X-ray-based Absorptiometry in Daily Clinical
Practice 69
10 Differential Diagnosis: Back Pain and Osteoporosis 75
11 Differential Diagnosis: Bone Pain and Fractures 87
12 Falls in Older People 93
13 Genes and Osteoporosis 101
Part 3 Treatment of Postmenopausal Osteoporosis
14 Prevention Early After Menopause 111
15 Pharmacologic and Non-pharmacologic Strategies to Prevent Hip
Fracture in Old Age 119
16 Selective Estrogen Receptor Modulators 129
17 Bisphosphonate Therapy for Postmenopausal Osteoporosis 133
18 Anabolic Drug Therapy in Osteoporosis 143
19 Surgical Therapy of Fractures 147
Part 4 Other Aspects of Osteoporosis
20 Osteoporosis in Men 155
21 Corticosteroid Osteoporosis 163
22 Tumor Bone Diseases 171
23 Immobilization, Exercise, and Osteoporosis 179
24 Nutrition and Osteoporosis 187
25 The Menopause: A Woman's View 193
Part 5 The Future of Diagnosis and Treatment of Osteoporosis
26 Future Developments: Risk Assessment 199
27 Future Therapies 209
28 How to Interpret New Data 213
Index 219