PARP as a Therapeutic Target-1판

Ch. 1 Nervous System Functions of Poly(ADP-Ribose) Polymerase-1
1
Ch. 2 Role of Poly(ADP-Ribose) Polymerase-1 in Neurologic
Disorders 19

Ch. 3 Involvement of PARP-1 and Poly(ADP-Ribosyl)ation in the
Maintenance of Genomic Stability 39
Ch. 4 Functional Testing of Human PARP in Proliferation,
Endotoxic Shock, and Radiosensitivity: A Genetic Rescue Study 67
Ch. 5 PARP Inhibitors as Neuroprotective Agents for Brain Injury
83
Ch. 6 PARP Inhibitors and Cardioprotection 117
Ch. 7 Neuroprotection of the Retina with 3-Aminobenzamide, a
PARP Inhibitor 135
Ch. 8 Poly(ADP-Ribose) Polymerase Inhibitors and Acute Renal
Failure 149
Ch. 9 Role of Poly(ADP-Ribose) Polymerase Activation in the
Pathogenesis of Shock and Inflammation 169
Ch. 10 Clinical Development of the Nicotinamides and Benzamides
Involving PARP as a Molecular Target 205
Ch. 11 Chemoprotective Effect of a Novel PARP Inhibitor 223
Ch. 12 Beneficial Effect of GPI 6150 Treatment in Multiple
Animal Models of Diseases 239
Ch. 13 Protecting Effect of PARP Inhibition on Ultraviolet Light-
Induced Skin Damage 257
Ch. 14 Role of Poly(ADP-Ribose) Polymerase Activation in the
Pathogenesis of Diabetes Mellitus and Diabetic Vascular
Dysfunction 277
Ch. 15 Therapeutic Targeting of the PARPs: Future Challenges,
Future Opportunities 321
Index 329