Cell Biology

1 General Principles of Cellular Organization 1
Basic Chemical and Physical Concepts 17
2 Molecular Structures 19
3 Basic Biophysical Concepts 43
4 Macromolecular Assembly 51
5 Research Strategies 67
Membrane Structure and Function 89
6 Membrane Structure and Dynamics 91
7 Membrane Pumps 105
8 Membrane Carriers 117
9 Membrane Channels 125
10 Membrane Physiology 149
Storage and Expression of Genetic Information 175
11 Introduction to Nuclear and Chromosomal Structure and
Function 177
12 Chromosome Organization 181
13 DNA Packaging in Chromatin and Chromosomes 197
14 Gene Expression 215
15 Processing of Eukaryotic RNAs 239
16 Nuclear Structure and Dynamics 259
Biogenesis, Traffic, and Functions of Cellular Membrane Systems
275
17 Introduction to Membrane Compartments 277
18 Protein Synthesis and Folding in the Cytoplasm 283
19 Post-Translational Targeting of Proteins to Organelles 297
20 Biosynthetic Processes in the Endoplasmic Reticulum and Golgi
Apparatus 311
21 Vesicular Traffic from the Endoplasmic Reticulum through the
Golgi Apparatus 327
22 Trans-Golgi Network and Beyond 341
23 Endocytosis 355
24 Degradation of Cellular Components 369
Reception and Transduction of Environmental Information 381
25 Introduction to Signaling Pathways 383
26 Plasma Membrane Receptors 387
27 Protein Hardware for Signaling 401
28 Second Messengers 423
29 Integration of Signals 445
Cellular Interactions and the Extracellular Matrix 471
30 Cells of the Extracellular Matrix 473
31 Extracellular Matrix Molecules 485
32 Cellular Adhesion 507
33 Intercellular Junctions 525
34 Specialized Connective Tissues 535
Cytoskeleton and Cellular Motility 551
35 Overview of the Cytoskeleton and Cellular Motility 553
36 Actin and Actin-Binding Proteins 557
37 Microtubules and Microtubule-Associated Proteins 579
38 Intermediate Filaments 595
39 Motor Proteins 605
40 Intracellular Motility 619
41 Cellular Motility 633
42 Muscles 651
Cell Cycle 671
43 Introduction to the Cell Cycle 673
44 The G[subscript 1] Phase and the Regulation of Cell
Proliferation 687
45 The S Phase and DNA Replication 697
46 The G[subscript 2] Phase and Control of Entry into Mitosis
713
47 Mitosis 725
48 Meiosis 749
49 Programmed Cell Death 767