Immunologically Mediated Endocrine Diseases

Contributing Authors
Series Preface
Preface
1 Basic Immunology 1
2 Autoantigen Processing 43
3 Immunological Tolerance: Is Self/non-self Discrimination
Required for Preventing Autoimmunity? 63
4 Immunobiology of Endocrine Gland Transplantation 83
5 Islet Immunoisolation 103
6 Pancreas Development 141
7 Classification of the Autoimmune
Polyglandular Syndromes 167
8 Transgenic Models in Autoimmunity 189
9 Oral Tolerance and Diabetes 201
10 Immunotherapies: Role of Peptides in the Generation and
Regulation of Autoimmunity 219
11 Immunotherapies: Immunosuppressive Therapy of T1D Through
Understanding Pathophysiology 237
12 Immunotherapies: Antigen Immunization Therapy 255
13 Prevention of IDD 267
14 Etiology/Pathogenesis of Type 1 Diabetes 287
15 Cytokines and the Pathogenesis of Type I Diabetes Mellitus
303
16 Epitope Mimicry in Autoimmune Diseases: Paying the Price for
Flexible Antigen Recognition by the T Cell Receptor 335
17 Epidemiology of Chronic Autoimmune Thyroiditis and Type 1
Diabetes 355
18 Autoimmune Thyroid Diseases 373
19 The Immunological Mediation of Robert Graves' Disease 397
20 Hypoparathyroidism 427
21 Addison's Disease 431
22 Autoimmune Gastritis 453
23 Ovarian Autoimmunity 475
24 Autoantibodies to the Insulin Receptor 489
25 Pathology/History of Organ-Specific Autoimmune Diseases 499
26 Immunological Markers and Disease Prediction 529
27 Celiac Disease: An Immunological Disorder 549
28 Considerations in the Design of Clinical Trials for Disease
Prevention 557
29 Vitiligo and Alopecia 565
30 Autoimmune Liver Diseases and Their Link to Endocrine
Disorders 573
31 Genetics of Immunologically Mediated Endocrine Diseases 591
32 Immunogenetics 631
33 The Role of Viruses 639
Subject Index 667