Chernick-Mellins: Basic Mechanisms of Pediatric Respiratory Disease

Foreword

I. Genetic and Developmental Biology of the Respiratory System
1. Approach to Pulmonary Diseases with a Genetic Basis
2. Genetic and Molecular Basis of Airway and Lung Development
3. Genetics of Lung Disease: Surfactant Protein B Deficiency
4. Developmental Biology of Surfactant

II. Structure-Function Relations of the Respiratory System
During Development
5. Mechanisms of Lung Vascular Development
6. Tissue Interactions in Lung Organogenesis
7. Prenatal and Postnatal Development of the Pulmonary
Circulation
8. Responses of the Developing Lung to Injury
9. Development of the Thoracic Cage
10. Structural and Functional Development of Respiratory Muscle

III. Developmental Physiology of the Respiratory System

MECHANICS
11. Respiratory Function in Infants
12. Comparative Aspects of Neonatal Respiratory Mechanics
13. Physiology of Cough

GAS EXCHANGE AND DELIVERY
14. Oxygen Transport
15. Pulmonary Gas Exchange
16. Tissue and Cellular Carbon Dioxide Transport and Acid-Base
Balance
17. Heart-Lung Interactions


RESPIRATORY MUSCLES
18. Respiratory Muscle Function: Implications for Ventilatory
Failure
19. Airway Smooth Muscle

LUNG LIQUID AND ION TRANSPORT
20. Pulmonary Edema and Injury to the Developing Lung
21. Ion Flux and Homeostasis in the Lung
22. Disorders of Ion Transport

CELL FUNCTION DURING HYPOXIA
23. Cellular and Molecular Mechanisms in Hypoxia Injury or
Adaptation
24. Effects of Hypoxia on the Developing Pulmonary Circulation
25. Regulation of Cerebral Vascular Function by Oxygen
26. Cardiopulmonary Physiology at Altitude

RESPIRATORY CONTROL
27. Laryngeal Function and Respiratory System Neural Reflexes
28. Fetal Respiratory Control and Changes at Birth
29. Postnatal Development of Respiratory Control
30. Sleep and Respiratory Control
31. Interacting Mechanisms of Physical Activity and Growth in
Children

IV Inflammation and Pulmonary Defense Mechanisms

32. Ciliary Abnormalities
33. Ciliogenesis of Airway Epithelium
34. Immunology and Cellular Defence Mechanisms in the Lung
35. Airway Secretions
36. Pulmonary Macrophages: Origins, Functions and Clearance
37. The Role of Oxidant Injury in the Pathogenesis of
Bronchopulmonary Dysplasia
38. Virus-induced Inflammation in Airways
39. Fibroproliferative Response: Molecular Mediators and
Pathophysiologic Relevance

Index

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