Pain: Current Understanding Emerging Therapies and Novel Approaches to Drug Discovery

Basic Aspects
Mechanism-Based Classifications of Pain and Analgesic Drug
Discovery
Clifford J. Woolf, David Borsook, and Martin Koltzenburg
Sites of Analgesic Action
Michael Hudspith and Rajesh Munglani
From Acute to Chronic Pain: Peripheral and Central Mechanisms
Fernando Cervero and Jennifer M. A. Laird
Central and Peripheral Components of Neuropathic Pain
R. W. Colburn and Rajesh Munglani
A New Perspective on Signal Transduction in Neuropathic Pain:
The Emerging Role of the G Protein Dimer in Transducing and
Modulating Opioid Signaling
Keith McCormack
Pain and the Somatosensory Cortex
Rolf-Detlef Treede
Descending Pathways in Spinal Cord Stimulation and Pain Control
Sumihisa Aida and Koki Shimoji
Local Neuroimmune Interactions in Visceral Hyperalgesia:
Bradykinin, Neurotrophins, and Cannabinoids
Andrew S. C. Rice
Pain Processing in the Periphery: Development of Analgesics
Andy Dray

Clinical Aspects
Neuroimaging of Pain: Possibilities of Objective Measurements of
Analgesic Actions in Human Subjects
David Borsook, Lino Becerra, Alison Comite, Gil Gonzalez, and
Hans Breiter
Surrogate Models of Pain
G. C. Preston
Acute Trauma and Postoperative Pain
Leslie M. Bromley
Effectiveness of Needling Techniques with Special Reference to
Myofascial Pain Syndromes
Andreas G. Erdmann, C. Chan Gunn, and Rajesh Munglani
Advances in the Management of Spinal Pain and Radiofrequency
Techniques
Andreas G. Erdmann and Rajesh Munglani
Pulsed Radiofrequency Treatment of Chronic Neck, Back,
Sympathetic, and Peripheral Neuroma뺻erived Pain
Rajesh Munglani and Kathrin A. Stauffer
Spinal Cord Stimulation
Y. Michael A. Tai and Julie. A. Payne
Spinal Endoscopy: Its Current Status and Role in Lumbosacral
Radiculopathy
Jonathan Richardson
Cancer Pain Treatment
Margaret Saunders and S. Booth
Inflammatory Joint Disease and Pain
S. Greer and B. L. Hazleman
Chronic Nonmalignant Visceral Pain Syndromes of the Abdomen,
Pelvis, and Bladder and Chronic Urogenital and Rectal Pain
Ursula Wesselmann
Nerve Injury Pain
Gudarz Davar
Sympathetically Maintained Pain
Ralf Baron and Wilfrid J?ig
Headache: Basic Anatomy and Physiology of the Trigeminovascular
System
Peter J. Goadsby
Psychological Factors in Measurement of Pain
Maria Koutantji and Shirley Pearce
Challenges and Pitfalls of Clinical Trials: Evaluating Novel
Analgesics for Neuropathic Pain
Christine Nai-Mei Sang

Novel Approaches to Drug Discovery
Molecular Approaches to the Study of Pain
Richard A. Newton, Sharon Bingham, Philip Davey, Andrew D.
Medhurst, Val Piercy, Pravin Raval, Andrew A. Parsons, Gareth J.
Sanger, C. Patrick Case, and Sally N. Lawson
Molecular Validation of Pain Targets
Simon Tate
Genetics of Pain
Philippe Sanseau and Karen Lewis
Animal Models of Pain
Philip J. Siddall and Rajesh Munglani

New and Emerging Therapies
An Overview of Current and Investigational Drugs for the
Treatment of Acute and Chronic Pain
William K. Schmidt
Novel Mu, Delta, and Kappa Agonists: Potential for Development
of Novel Analgesic Agents
Frank Porreca and Victor J. Hruby
Delta-Receptor, Nonpeptide Agonists: The Development of Safe,
Strong Analgesics with a Novel Mechanism of Action
Hugh O. Pettit and Kwen-Jen Chang
Peripheral Opioid Analgesia: Neuroimmune Interactions and
Therapeutic Implications
Halina Machelska and Christoph Stein
Profile of ADL 2-1294, an Opioid Antihyperalgesic Agent with
Selectivity for Peripheral Mu-Opiate Receptors
Diane L. DeHaven-Hudkins
Controlled-Release Opioids
Allan J. Miller and Kevin J. Smith
NMDA-Receptor Antagonists as Enhancers of Analgesic Activity:
The MorphiDexTM Morphine뾆extromethorphan Combination
Frank S. Caruso, Donald D. Price, David J. Mayer, Jianren Mao,
Eileen M. Shalhoub, and Ronald Goldblum
CCK Antagonist Potentiation of Opioid Analgesia
Leslie L. Iversen
Profile of NSAID + Opioid Combination Analge