Functional Neurobiology of Aging

Foreword.
Preface.
I. Overview:
Introduction to Concepts in Aging Research:
Age-Specific Rates of Neurological Disease.
Nature versus Nurture in the Aging Brain.
Neurochemistry of Receptor Dynamics in the Aging Brain.
Epidemiology of Neural Aging:
Demography and Epidemiology of Age-Associated Neuronal
Impairment.
II. Memory: Neocortical and Hippocampal Functions:
Neuropsychology of Human Aging.
Memory Changes with Aging and Dementia.
Histology of Age-Related Cortical Changes in Humans:
Types of Age-Related Brain Lesions and Relationship to
Neuropathological Diagnostic Systems of Alzheimer's Disease.
Morphological changes in Human Cerebral Cortex during Normal
Aging.
Longevity and Brain Aging: The Paradigm of Centenarians.
Alzheimer's Disease:
Regional and Laminar Patterns of Selective Neuronal
Vulnerability in Alzheimer's Disease.
Patterns of Cortical Neurodegeneration in Alzheimer's Disease:
Subgroups, Subtypes, and Implications for Staging Strategies.
Non-Alzheimer Age-Associated Dementing Disorders:
Vascular Dementia.
Frontotemporal Dementias: From Classification Problems to
Pathogenetic Uncertainties.
Progressive Supranuclear Palsy and Corticobasal Degeneration.
Neurobiology of Disorders with Lewy Bodies.
Amyotrophic Lateral Sclerosis/Parkinsonism-Dementia Complex of
Guam.
In Vivo Imaging of Aging Brain:
Brain Energy Metabolism: Cellular Aspects and Relevance to
Functional Brain Imaging.
Functional Imaging in Cognitively Intact Aged People.
Functional Brain Studies of the Neurometabolic Bases of
Cognitive and Behavioral Changes in Alzheimer's Disease.
Biochemical Correlates of Memory Impairments:
Cholinergic Basal Forebrain Systems in the Primate Central
Nervous System: Anatomy, Connectivity, Neurochemistry, Aging,
Dementia, and Experimental Therapeutics.
Glutamate Receptors in Aging and Alzheimer's Disease.
Tau Phosphorylation.
Hereditary Basis of Alzheimer's Disease and Related Dementias:
Etiology, Genetics, and Pathogenesis of Alzheimer's Disease.
Nonhereditary Mechanisms of Alzheimer's Disease:
Inflammation, Free Radicals, Glycation, Metabolism and
Apoptosis, and Heavy Metals.
Rodent Models of Age-Related Memory Impairments:
Rodent Models of Age-Related Memory Impairments.
Genetically Engineered Models of Human Age-Related
Neurogenerative Diseases.
Nonhuman Primate and Other Vertebrate Models of Brain Aging:
Cognitive Aging in Nonhuman Primates.
Brain Aging in Strepsirhine Primates.
Age-Related Morphologic Alterations in the Brain of Old World
and New World Anthropoid Monkeys.
The Study of Brain Aging in Great Apes.
Neurobiological Models of Aging in the Dog and Other Vertebrate
Species.
Interventions:
Estrogens and Alzheimer's Disease.
Cholinergic Treatments of Alzheimer's Disease
Anti-Inflammatory and Antioxidant Therapies in Alzheimer's
Disease.
III. Senses: Sensory Cortices and Primary Afferent Functions:
Vision:
The Retina in Aging and in Alzheimer's Disease.
Pathogenesis of Glaucomatous Optic Neuropathy.
Color Vision, Object Recognition, and Spatial Localization in
Aging and Alzheimer's Disease.
Hearing:
Anatomical and Neurochemical Bases of Presbycusis.
Age, Noise, and Ototoxic Agents.
Auditory Temporal Processing during Aging.
Neurophysiological Manifestations of Aging in the Peripheral and
Central Auditory Nervous System.
Genetics and Age-Related Hearing Loss.
Animal Models of Presbycusis and the Aging Auditory System.
The Development of Animal Models for the Study of Presbycusis:
Building a Behavioral Link between Perception and Physiology.
Rehabilitation for Presbycusis.
Chemical Senses:
Olfaction and Gustation in Normal Aging and Alzheimer's Disease.
IV. Locomotion: Basal Ganglia and Muscular Functions:
Functional Impairments in Humans:
Aging Effects on Muscle Properties and Human Performance.
Parkinson's Disease: Symptoms and Age Dep