Alzheimer Disease: The Changing View

Preface
Ch. 1 Setting the Stage 1
Ch. 2 The Pioneers 11
The Ultrastructure of AD 11
Cognitive Decline in the Elderly and AD Pathology - The First
Prospective Study: Newcastle 46
Ch. 3 The Need for Care 97
The Impact on Families 97
Designing the First Special Care Unit 114
Ch. 4 Understanding the Biology of AD 127
Experimental Models 127
Genetics 150
Leonard Hetson
Ch. 5 The Cholinergic Story: Hope for the Patient and Family 167
Clues and Chemical Leads: Scopolamine Impairs Cognition 167
The Loss of Cholinergic Markers in the AD Brain 179
Ch. 6 Improving the Accuracy of Diagnosis 211
Ch. 7 The Impact of AD and Society's Response 237
Demography 237
Public Health Impact 252
The National Institutes of Health Respond 272
The Rise of the Alzheimer's Association 312
Ch. 8 The Next Act 353
Index 379