Physiology of the Heart 4/e

Preface to the First Edition
Preface
Acknowledgments
1 Structure of the Heart and Cardiac Muscle 1
2 Membrane Structure and Function 37
3 Energetics of Muscle 63
4 Anaerobic and Aerobic Glycolysis 74
5 Oxidative Metabolism 98
6 Energy Utilization (Work and Heat) 129
7 Contractile Proteins 151
8 Mechanism and Control of the Cardiac Contractile Process 178
9 Series Elasticity, "Active State," Length-Tension Relationship, and Cardiac
Mechanics 196
10 Excitation-Contraction Coupling: Calcium and Other Ion Fluxes Across the
Plasma Membrane 219
11 Excitation-Contraction Coupling: Calcium Fluxes Across the Sarcoplasmic
Reticulum and Mitochondria 243
12 Receptors, Coupling Proteins, and Second Messengers 274
13 Myocardial Contractility: Force, Velocity, Length, and Time 303
14 Regulation of Myocardial Contractility 319
15 The Heart as a Muscular Pump 351
16 The Working Heart 369
17 Indices of Myocardial Contractility and Relaxation 396
18 Ion Channels of the Heart 415
19 The Cardiac Action Potential 438
20 The Electrocardiogram 473
21 The Arrhythmias: I. Introduction and Mechanisms 515
22 The Arrhythmias: II. Conduction Abnormalities and Block 546
23 The Arrhythmias: III. Premature Systoles, Tachycardias, Flutter, and
Fibrillation 569
24 The Ischemic Heart 609
25 Heart Failure 638
Subject Index 669