Pancreatic Cancer

Table of Contents
Series Preface
Preface
Contributors
Pt. I Epidemiology/Molecular Biology 1
1 Molecular Epidemiology 3
2 The Molecular Biology of Pancreatic Cancer 15
3 Molecular Markers as a Tool for the Early Diagnosis of
Pancreatic Cancer 29
4 Cell Signaling Pathways in Pancreatic Cancer 47
5 Epithelial Stem Cells in Pancreatic Regeneration and Neoplasia
63
6 Inherited Pancreatic Cancer Syndromes 73
Pt. II Staging 83
7 Pancreatic Cancer: Radiologic Staging 85
8 Endoscopic Diagnosis and Staging: Endoscopic Ultrasound,
Endoscopic Retrograde Cholangiopancreatography 97
9 Laparoscopic Staging 115
Pt. III Surgery/Therapeutic Endoscopy/Pain Management 123
10 Whipple Procedure: 1935 to Present 125
11 Regional Lymph Node Dissection for Pancreatic Adenocarcinoma
139
12 Pylorus Preservation versus Standard Pancreaticoduodenectomy:
Oncologic Controversies 153
13 Vascular Resection and Reconstruction for Localized
Pancreatic Cancer 161
14 Techniques for Biliary and Pancreatic Reconstruction After
Pancreaticoduodenectomy 171
15 Transduodenal Local Resection for Periampullary Neoplasms 181
16 Distal Pancreatectomy for Pancreatic Cancer 193
17 Risks of Perioperative Mortality with Pancreaticoduodenectomy
201
18 Endoscopic Palliation for Locally Advanced and Metastatic
Disease: Biliary and Duodenal Stents 213
19 Celiac Plexus Block versus Systemic Opioid Medication in the
Management of Pancreatic Cancer Pain 223
Pt. IV Multimodality Therapy 233
20 Postoperative Adjuvant Therapy: Past, Present, and Future
Trial Development 235
21 Preoperative (Neoadjuvant) Therapy for Resectable
Adenocarcinoma of the Pancreas 243
22 European Adjuvant Trials 255
23 Adjuvant Regional Infusion Therapy
A Two-Channel Chemotherapy to Prevent Hepatic Metastasis After
Extended Pancreatectomy for Adenocarcinoma of the Pancreas: The
Osaka Experience 269
B Adjuvant Intra-arterial Chemotherapy With and Without
Radiation Therapy in Pancreatic Cancer: The Ulm Experience 275
C Locoregional Targeting Immunochemotherapy for Resectable and
Unresectable Pancreatic Head Carcinoma: The Athens Experience
280
24 Intraoperative Radiation for Pancreatic Cancer 287
25 Conformal Radiation Therapy in Pancreatic Cancer 295
26 Radiation Sensitizers, Fractionation Schedules, and Future
Clinical Trials 301
27 Cytotoxic Chemotherapy for Pancreatic Cancer: Past, Present,
and Future 311
Pt. V Emerging Therapies 321
28 Animal Models of Pancreatic Adenocarcinoma 323
29 Strategies for Gene Therapy 331
30 Photodynamic Therapy and Endoscopic Ultrasound-Guided Therapy
for Pancreatic Cancer 343
31 Vaccine Therapy for Pancreatic Cancer 347
32 Antiangiogenic Strategies in Pancreatic Cancer 357
33 Role of Matrix Metalloproteinase Inhibition in the Treatment
of Pancreatic Cancer 369
34 Regulation of Pancreatic Cancer Growth by Gastrointestinal
Hormones: A Clinically Useful Strategy? 377
35 Farnesyltransferase Inhibitors: Biological Considerations for
Future Therapeutics 389
36 Novel Therapeutic Targets for Drug Development 397
Index 407