The Molecular Basis of Blood Disease

PART I: Hematopoiesis
Stem Cell Biology
Hemopoietic Growth Factors and Receptors
Transcriptional Factors that Regulate Lineage Decisions
Growth Factor Signaling

PART II: Red Cells
Hemoglobin Switching
The Thalassemias
Human Hemoglobins: Sickle Cell Hemoglobin and Other Mutants
The Erythrocyte Membrane and Cytoskeleton: Structure, Function,
and Disorders
Red Blood Cell Antigenes
Molecular Basis of Iron Metabolism

PART III: Lymphopoiesis
Gene rearrangements in Lymhoic Cells
Lymphoiesis
Antigen Processing and T-Cell Effector Mechanisms

PART IV: Myelopoiesis/White Blood Cells
Integrins, Selectins, and LAD
Chemokines
Genetic Disorders of Phagocyte Function
Paroxymal Nocturnal Hemoglobins

PART V: Hemostasis
Vitamin K-Dependent Proteins
The Protein C Anticoagulant System
Regulation of Blood Coagulation by Protease Inhibitors
Hemophilia A, Hemophilia B, and von Willenbrand Disease
The Molecular Basis of Fibrin
Fibrinilysis and the Control of Hemostasis
Platelets

PART VI: Molecular Oncology
Molecular Aspects of Oncogenesis
Mechanisms of Leukemogenesis

PART VII: Viruses
The Molecular and Biological Properties of the Human
Immunodeficiency Virus
Viral Pathogenesis of Hematological Disorders
B19 Parvoviruses
HTLVs
Herpesviruses
Gene Therapy of Hemopoietic Diseases