Radiopharmaceutical Therapy

This book covers foundational topics in the emerging field of radiopharmaceutical therapy.
It is divided into three sections: fundamentals, deeper dives, and special topics.
In the first section, the authors examine the field from a bird’s-eye view, covering topics including the history of radiopharmaceutical therapy, the radiobiology of radiopharmaceutical therapy, and the radiopharmaceutical chemistry of
both metallic and non-metallic radionuclides.
The second section provides a more in-depth look at specific radiotherapeutics.
Chapters include broader discussions of the different platforms for radiopharmaceutical therapy as well as more focused case studies covering individual radiotherapeutics.
The third and final section explores a number of areas for further study, including medical physics, artificial intelligence, in vivo pretargeting, theranostic imaging, and the regulatory review process for radiotherapeutics.

This book is the first of its kind andis useful for a broad audience of scientists, researchers, physicians, and students across a range of fields, including biochemistry, cancer biology, nuclear medicine, radiology, and radiation oncology.




Introduction: The Case for Radiopharmaceutical Therapy

A Brief History of Radiopharmaceutical Therapy

The Nuclear Chemistry of Therapeutic Radionuclides

The Production of Therapeutic Radionuclides

The Radiobiology of Radiopharmaceutical Therapy: The Input of Imaging and Radiomics

The Radiopharmaceutical Chemistry of Metallic Radionuclides

The Radiopharmaceutical Chemistry of the Halogen Radionuclides

Dosimetry in Radiopharmaceutical Therapy

Front Matter

Antibodies as Vectors for Radiopharmaceutical Therapy

Case Study #1: Alpha Particle Therapy of Leukemia Using 225Ac-Lintuzumab

Case Study #2: Disialoganglioside GD2 as a Target for Radiopharmaceutical Therapy

Case Study #3: Antibody Fragments in Radiopharmaceutical Therapy

Peptides as Vectors for Radiopharmaceutical Therapy

Case Study #4: Lutathera, a Gold Standard for Peptide Receptor Radiopharmaceutical Therapy

Case Study #5: CXCR4-Targeted Radiotherapeutics

Case Study #6: [177Lu]Lu-DOTA-JR11: A Somatostatin Receptor Subtype 2 Antagonist for Radiopharmaceutical Therapy

Small Molecules as Vectors for Radiopharmaceutical Therapy

Auger Electron-Emitting Radionuclides in Radiopharmaceutical Therapy

Pretargeted Radiopharmaceutical Therapy

Theranostic Imaging and Radiopharmaceutical Therapy

The Next Generation of Therapeutic Radionuclides

Artificial Intelligence and Machine Learning

The Regulatory Review of Radiotherapeutics: United States of America

The Regulatory Review of Radiotherapeutics: A European Perspective

The Regulatory Review of Radiotherapeutics: A Japanese Perspective

Radiotherapeutics and Nuclear Pharmacy

Back Matter