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Long recognized as the authoritative leader in the field, Creasy and Resnik's Maternal-Fetal Medicine, 8th Edition,
continues to provide the latest evidence-based guidelines for obstetric and neonatal management, helping you
minimize complications and offer patients the best possible care. Written by renowned experts in obstetrics,
gynecology, and perinatology, this comprehensive resource has been thoroughly updated and reflects new
information in every area, including recent tremendous advances in genetics, imaging, and more.
• Focuses on complicated obstetric issues, highlighting the most commonly encountered anomalies and
providing clear guidelines for obstetric and neonatal management.
• Offers comprehensive updates on rapidly changing topics, including a completely revised section on
genetics and genetic technology for prenatal diagnoses, as well as an expanded imaging section
accompanied by new videos on abdominal, urogenital, and skeletal imaging.
• Includes four new chapters: Molecular Genetic Technology, MRI in Obstetrical Imaging, Obesity in
Pregnancy, and Pregnancy as a Window to Future Health.
• Features numerous flow charts for quick access to diagnosis and treatment protocols and to clarify complex
material.
• Presents the knowledge and expertise of new editors Dr. Joshua Copel, an expert in the field of fetal therapy
who has pioneered new diagnostic techniques for unborn patients and their mothers, and Dr. Robert Silver, a
leader in the maternal-fetal medicine community.
• Expert Consult™ eBook version included with purchase. This enhanced eBook experience allows you
to search all of the text, figures, and references from the book on a variety of devices.
PART 1 : SCIENTIFIC BASIS OF PERINATAL BIOLOGY
1. Human Basic Genetics and Patterns of Inheritance, 3
2. Molecular Genetic Technology, 15
3. Normal Early Development, 39
4. Amniotic Fluid Dynamics, 62
5. Multiple Gestation: The Biology of Twinning, 68
6. Physiology of Parturition, 81
7. Pathogenesis of Spontaneous Preterm Birth, 96
8. Immunology of Pregnancy, 127
9. Maternal Cardiovascular, Respiratory, and Renal Adaptation to Pregnancy, 141
10. Endocrinology of Pregnancy, 148
11. The Breast and the Physiology of Lactation, 161
12. Maternal Nutrition, 181
13. Fetal Cardiovascular Physiology, 190
14. Behavioral States in the Fetus: Relationship to Fetal Health and Development, 200
15. Placental Respiratory Gas Exchange and Fetal Oxygenation, 210
16. Fetal Lung Development and Surfactant, 223
17. Evidence-Based Practice in Perinatal Medicine, 235
PART 2 : OBSTETRIC IMAGING
Section I . Principles of Fetal Imaging, 251
18. Performing and Documenting the Fetal Anatomy Ultrasound Examination, 252
19. Doppler Ultrasound: Select Fetal and Maternal Applications, 266
20. Clinical Applications of Three-Dimensional Sonography in Obstetrics, 274
21. MRI in Obstetrical Imaging, 294
Section II . Lesions, 303
22. Central Nervous System Imaging, 304
22A Cephalocele, 304
22B Choroid Plexus Cysts, 307
22C Holoprosencephaly, 310
22D Porencephalic Cyst, 313
22E Ventriculomegaly: Aqueductal Stenosis, 317
22F Ventriculomegaly: Arnold-Chiari Malformation, 321
22G Ventriculomegaly: Borderline Lateral Cerebral Ventriculomegaly, 324
22H Ventriculomegaly: Dandy-Walker Malformation and Variant, 327
22I Agenesis of the Corpus Callosum, 329
22J Arachnoid Cyst, 329
22K Exencephaly and Anencephaly, 329
22L Hydranencephaly, 329
22M Microcephaly, 329
22N Vein of Galen Aneurysm, 329
23. Imaging of the Face and Neck, 330
23A Cleft Lip and Palate, 330
23B Cystic Hygroma, 334
23C Micrognathia, 337
23D Abnormal Orbits, 339
23E Goiter, 339
24. Thoracic Imaging, 340
24A Congenital Diaphragmatic Hernia, 340
24B Cystic Lung Lesions, CPAM/CCAM, and Sequestration, 344
24C Congenital High Airway Obstruction, 347
24D Pleural Effusion, 347
25. Fetal Cardiac Malformations and Arrhythmias: Detection, Diagnosis, Management, and Prognosis, 348
26. Abdominal Imaging, 393
26A Abdominal Ascites, 393
26B Intestinal Atresias, 396
26C Gastroschisis, 400
26D Omphalocele, 404
26E Cystic Abdominal Lesions, 407
26F Echogenic Abdominal Lesions, 410
26G Limb-Body Stalk Lesions, 413
26H Umbilical Vein Varix, 413
26I Esophageal Atresia, 414
27. Urogenital Imaging, 414
28. Skeletal Imaging, 433
29. Placenta and Umbilical Cord Imaging, 457
29A Marginal and Velamentous Umbilical Cord Insertion, 457
29B Molar Gestation, 460
29C Placenta Accreta-Increta-Percreta, 462
29D Placental Echolucencies: Lakes, Cysts, Chorangioma, 465
29E Placenta Previa, 468
29F Single Umbilical Artery, 471
29G Amniotic Fluid Volume, 473
29H Circumvallate Placenta, 473
29I Subchorionic Hematoma, 473
29J Succenturiate Placenta, 473
29K Vasa Previa, 473
30. Uterus and Adnexae Imaging, 474
30A Adnexal Mass, Complex and Simple, 474
30B Uterine Anomalies, 477
30C Uterine Myomas, 480
31. First-Trimester Imaging, 483
31A Fetal Structural Anomalies, 483
31B Nuchal Translucency, 487
31C Nasal Bone, 489
PART 3 : FETAL DISORDERS: DIAGNOSIS AND THERAPY
32. Prenatal Diagnosis of Congenital Disorders, 493
33. Teratogenesis and Environmental Exposure, 539
34. Assessment of Fetal Health, 549
35. Intrapartum Fetal Surveillance, 564
36. Assessment and Induction of Fetal Pulmonary Maturity, 583
37. Invasive Fetal Therapy, 594
38. Hemolytic Disease of the Fetus and Newborn, 632
39. Nonimmune Hydrops, 645
40. Multiple Gestation: Clinical Characteristics and Management, 654
PART 4 : DISORDERS AT THE MATERNAL-FETAL INTERFACE
41. Prevention and Management of Preterm Parturition, 679
42. Premature Rupture of the Membranes, 712
43. Clinical Aspects of Normal and Abnormal Labor, 723
44. Recurrent Pregnancy Loss, 758
45. Stillbirth, 769
46. Placenta Previa, Placenta Accreta, Abruptio Placentae, and Vasa Previa, 786
47. Intrauterine Growth Restriction, 798
48. Pregnancy-Related Hypertension, 810
PART 5 : MATERNAL COMPLICATIONS
49. Patient Safety in Obstetrics, 841
50. Maternal Mortality, 852
51. Maternal and Fetal Infections, 862
52. Cardiac Diseases, 920
53. Coagulation Disorders in Pregnancy, 949
54. Thromboembolic Disease in Pregnancy, 977
55. Anemia and Pregnancy, 991
56. Malignancy and Pregnancy, 1007
57. Renal Disorders, 1025
58. Respiratory Diseases in Pregnancy, 1043
59. Diabetes in Pregnancy, 1067
60. Obesity in Pregnancy, 1098
61. Thyroid Disease and Pregnancy, 1116
62. Other Endocrine Disorders of Pregnancy, 1135
63. Gastrointestinal Disease in Pregnancy, 1158
64. Diseases of the Liver, Biliary System, and Pancreas, 1173
65. Pregnancy and Rheumatic Diseases, 1192
66. Neurologic Disorders, 1208
67. Management of Depression and Psychoses in Pregnancy and in the Puerperium, 1232
68. Substance Abuse in Pregnancy, 1243
69. The Skin and Pregnancy, 1258
70. Anesthesia Considerations for Complicated Pregnancies, 1269
71. Intensive Care Considerations for the Critically Ill Parturient, 1285
72. Pregnancy as a Window to Future Health, 1300
PART 6 : THE NEONATE
73. Neonatal Morbidities of Prenatal and Perinatal Origin, 1309
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